71590-32-4Relevant articles and documents
Industrial preparation method of 6-bromonaphthalene-1, 2-diamine
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Paragraph 0004-0005; 0013, (2021/04/21)
The invention discloses an industrial preparation method of 6-bromonaphthalene-1, 2-diamine. The method comprises the following steps of: S1, making a compound III react with acetic anhydride in the presence of alkali and a catalyst to obtain a compound IV; S2, in the presence of acetic anhydride and nitric acid, taking acetic acid as a reaction solvent, performing reacting and purifying on the compound IV obtained in the step S1 to generate a compound V; S3, adding the compound V obtained in the above step into a solvent for dissolving the compound V, then adding a metal reducing agent and an ammonium chloride solution, heating to carry out a reaction for 6h, performing centrifugal filtering after finishing the reaction to obtain a filtrate, washing the filtrate with a sodium chloride solution, and performing concentrating to obtain a compound VI; and S4, adding the compound VI obtained in the previous step into a methanol solution, dropwise adding strong acid, replacing the solvent after finishing the reaction, performing crystallizing and filtering to obtain a compound 8. According to the method, the process is optimized, large-scale production can be achieved, applied materials are all commercial reagents, the cost is reduced, and the operation convenience is improved.
COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS AND PHARMACEUTICAL USES THEREOF
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Paragraph 00248; 00249, (2016/09/26)
The invention provides compounds as hepatitis C virus inhibitors and pharmaceutical uses thereof. Specifically, the invention provides compounds of Formula (I) or a stereoisomer, a tautomer, an enantiomer, an N-oxide, a hydrate, a solvate, a metabolite, a
FUSED TRICYCLIC COMPOUNDS AND DERIVATIVES THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES
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, (2011/06/23)
The present invention relates to novel fused tricyclic compounds, compositions comprising at least one fused tricyclic compound, and methods of using fused tricyclic compounds for treating or preventing a viral infection or a virus-related disorder in a patient.