71704-67-1

Basic information

• Product Name: 1H-Imidazole-4-carboxylicacid,5-methyl-,hydrazide(9CI)
• Synonyms: 1H-Imidazole-4-carboxylicacid,5-methyl-,hydrazide(9CI)
• CAS NO: 71704-67-1
• Molecular Formula: C₅H₈N₄O
• Molecular Weight: 140.14
• Product Categories: AMIDE
• Mol File: 71704-67-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Imidazole-4-carboxylicacid,5-methyl-,hydrazide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4-carboxylicacid,5-methyl-,hydrazide(9CI)(71704-67-1)
• EPA Substance Registry System: 1H-Imidazole-4-carboxylicacid,5-methyl-,hydrazide(9CI)(71704-67-1)

Safety Data

• Hazardous Substances Data: 71704-67-1(Hazardous Substances Data)

Usage

Molecular mass

168.15 g/mol The molecular mass of the compound is the sum of the atomic masses of all the atoms in the molecule, which in this case is 168.15 grams per mole.

Imidazole derivative

The compound is derived from imidazole, which is a heterocyclic aromatic organic compound with a five-membered ring structure containing four carbon atoms and one nitrogen atom.

Hydrazide functionality

The compound contains a hydrazide group (-NHNH2), which is a functional group consisting of two nitrogen atoms and two hydrogen atoms, known for its ability to form various chemical reactions and act as a reducing agent.

Potential uses

Organic synthesis and pharmaceutical research The compound has potential applications in the synthesis of various biologically active molecules, making it a valuable intermediate in the preparation of pharmaceuticals and other organic compounds.

Toxicity and reactivity

Handle with caution Due to its potential toxicity and reactivity, it is important to handle this compound with care and follow appropriate safety protocols.

Safety precautions

Well-ventilated area When working with 1H-Imidazole-4-carboxylic acid, 5-methyl-, hydrazide (9CI), it is important to work in a well-ventilated area to minimize the risk of exposure to harmful vapors or fumes.

Upstream product

• 51605-32-4 ethyl 4⁽⁵⁾-methylimidazole-5⁽⁴⁾-carboxylate 
• 78892-68-9 5-methyl-4-imidazole carboxylic acid methyl ester 
• 51605-32-4 Ethyl 5-Methyl-4-imidazolecarboxylate 
• 29636-87-1 4⁽⁵⁾-methyl-5⁽⁴⁾-hydroxymethylimidazole 
• 64-17-5 ethanol 

Downstream Products

• 117267-51-3 8-bromo-6-(2-chlorophenyl)-1-(5-methyl-4-imidazolyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 117267-53-5 N¹-(7-bromo-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-yl)-N²-(5-methyl-4-imidazolylcarbonyl)hydrazine 
• 117267-50-2 8-chloro-1-(5-methyl-4-imidazolyl)-6-phenyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 117291-09-5 8-chloro-6-(2-chlorophenyl)-1-(5-methyl-4-imidazolyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 117267-52-4 N¹-(7-chloro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2-yl)-N²-(5-methyl-4-imidazolylcarbonyl)hydrazine 
• 308305-50-2 (isopropylidene)-5-methyl-imidazole-4-carbohydrazide 
• 349629-96-5 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide 
• 1246611-17-5 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-(4-chlorophenyl)thiosemicarbazide 
• 349630-19-9 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-(4-fluorophenyl)thiosemicarbazide 
• 1260230-18-9 4-(2-fluorophenyl)-1-(4-methylimidazol-5-yl-carbonyl)-thiosemicarbazide 
• 1260230-24-7 4-(2-fluorophenyl)-5-(4-methylimidazol-5-yl)-s-triazole-3-thione 
• 349629-96-5 1-(4-methylimidazol-5-yl-carbonyl)-4-phenylthiosemicarbazide 
• 1260230-22-5 5-(4-methylimidazol-5-yl)-4-phenyl-s-triazole-3-thione 
• 1457-59-6 4⁽⁵⁾-methylimidazole-5⁽⁴⁾-carboxylic acid 

Relevant articles and documents

Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles

In this work we reported the synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities in vitro of three new compound series obtained from ethyl(5-methyl-1-H-imidazole-4-carboxylate): acylthiosemicarbazide analogues 3a-d, 4-thiazolidinone analogues 4a-d and 1,3,4-thiadiazole analogues 5a-d. All synthesized compounds were characterized by IR, 1H, 13C NMR and HRMS. The majority of the tested compounds show excellent anti-T. gondii activity when compared to hydroxyurea and sulfadiazine. In addition it was also shown that most of the compounds in this study have a better performance against intracellular tachyzoites. The results for antimicrobial activity evaluation showed weak antibacterial and antifungal activities for all the tested molecules, when compared with the standard drugs (chloramphenicol and rifampicin for antibacterial activity; nistatin and ketoconazole for antifungal activity).

Design and synthesis of novel potent antinociceptive agents: Methyl-imidazolyl N-acylhydrazone derivatives

This paper describes recent results of design, synthesis and pharmacological evaluation of new N-heterocyclic functionalized N-acylhydrazone compounds, belonging to the 2-methyl-imidazolyl-3-acylhydrazone class (4a-e). These compounds were planned by applying the molecular simplification strategy to propose the structural modifications on the previously described functionalized imidazo[1,2-a]pyridine 3-acylhydrazone series (2), which presented an important analgesic profile. This new series (4) was synthesized in order to investigate the possible pharmacophoric contribution of the N-heteroaromatic ring and N-acylhydrazone moieties to the analgesic activity. Compounds 4a-b are the most potent antinociceptive agents from this series. Copyright (C) 2000 Elsevier Science Ltd.

Method of treating hypertension using substituted imidazo[1,5-d]1,2,4-triazin-1(2H)-ones

This disclosure describes compositions of matter containing certain substituted imidazo[1,5-d]-1,2,4-triazin-1(2H)-ones and the method of treating hypertension therewith.