7174-27-8

Basic information

• Product Name: (R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE
• Synonyms: VASICINE HYDROCHLORIDE;(-)-peganinehydrochloride;1-b)quinazolin-3-ol,1,2,3,9-tetrahydro-,monohydrochloride,(r)-pyrrolo(;linarinehydrochloride;peganinehydrochloride;(R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE;VASICINE HCL(SH);(3S)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol monohydrochloride
• CAS NO: 7174-27-8
• Molecular Formula: C₁₁H₁₂N₂O*ClH
• Molecular Weight: 224.69
• Mol File: 7174-27-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 206-208℃
• Boiling Point: 373.8°C at 760 mmHg
• Flash Point: 179.9°C
• Appearance: /
• Vapor Pressure: 2.98E-06mmHg at 25°C
• CAS DataBase Reference: (R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE(7174-27-8)
• EPA Substance Registry System: (R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE(7174-27-8)

Safety Data

• Hazardous Substances Data: 7174-27-8(Hazardous Substances Data)

Usage

Description

(R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE is a chiral compound belonging to the quinazoline alkaloid class, characterized by its unique chemical structure and properties. It is derived from natural sources and has potential applications in various fields due to its pharmacological properties.

Uses

Used in Pharmaceutical Industry:
(R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE is used as a key intermediate for the synthesis of various pharmacologically active compounds. Its unique structure allows it to serve as a building block in the development of new drugs with potential therapeutic applications.
Used in Drug Discovery:
(R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE is used as a starting material for the preparation of Vicinal Tricarbonyls and cyano analogs. These electrophilic participants are crucial in forming pharmacophoric templates, which are essential for drug discovery and the development of novel therapeutic agents.
Used in Chemical Research:
(R)-1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL HYDROCHLORIDE is utilized as a research compound in the field of organic chemistry. Its unique properties make it a valuable tool for studying reaction mechanisms, exploring new synthetic routes, and understanding the structure-activity relationships of quinazoline-based compounds.

InChI:InChI=1/C11H12N2O.ClH/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13;/h1-4,10,14H,5-7H2;1H/t10-;/m0./s1

Upstream product

• 6159-56-4 vasicine 
• 158734-31-7 vasicol 

Downstream Products

• 82083-78-1 3-[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline 
• 82083-84-9 5-[1,2-Dihydro-9H-pyrrolo[2,1-b]quinazolin-(3E)-ylidenemethyl]-2-methoxy-phenol 
• 82083-83-8 4-[1,2-Dihydro-9H-pyrrolo[2,1-b]quinazolin-(3E)-ylidenemethyl]-2-methoxy-phenol 
• 82083-80-5 2-[1,2-Dihydro-9H-pyrrolo[2,1-b]quinazolin-(3E)-ylidenemethyl]-phenol 
• 82083-76-9 3-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline 
• 82083-77-0 3-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline 
• 82083-79-2 3-[1-p-Tolyl-meth-(E)-ylidene]-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline 
• 82083-75-8 3-benzylidene-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline 
• 495-59-0 deoxypeganine 

Relevant articles and documents

VASICOL, A NEW ALKALOID FROM ADHATODA VASICA

Key Word Index - Adhatoda vasica; Acanthaceae; alkaloids; 1,2,3,4,9,11-hexahydro pyrrolo quinazolin-3,11 diol; vasicinone. A novel alkaloid isolated from the roots of Adhatoda vasica has been characterized as 1,2,3,4,9,11 hexahydro pyrrolo (2,1-b) quinazolin-3,11 diol by chemical and spectroscopic methods.Vasicinone has also been isolated from the roots of this plant.