7175-09-9

Basic information

• Product Name: 7-bromo-5-methylquinolin-8-ol
• Synonyms: 7-bromo-5-methylquinolin-8-ol;7-Bromo-5-methyl-8-quinolinol
• CAS NO: 7175-09-9
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• EINECS: 230-533-6
• Product Categories: API
• Mol File: 7175-09-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 160 °C(Solv: ethanol (64-17-5))
• Boiling Point: 342.2°C at 760 mmHg
• Flash Point: 160.8°C
• Appearance: /
• Density: 1.612g/cm³
• Vapor Pressure: 3.86E-05mmHg at 25°C
• Refractive Index: 1.692
• PKA: 3.79±0.30(Predicted)
• CAS DataBase Reference: 7-bromo-5-methylquinolin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-5-methylquinolin-8-ol(7175-09-9)
• EPA Substance Registry System: 7-bromo-5-methylquinolin-8-ol(7175-09-9)

Safety Data

• Hazardous Substances Data: 7175-09-9(Hazardous Substances Data)

Usage

Description

7-bromo-5-methylquinolin-8-ol is an organic compound belonging to the quinoline family, characterized by the presence of a bromine atom at the 7th position, a methyl group at the 5th position, and a hydroxyl group at the 8th position. It is known for its potential applications in various fields due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
7-bromo-5-methylquinolin-8-ol is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential therapeutic applications. Its unique structure allows for the development of new drugs with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
In the field of organic chemistry, 7-bromo-5-methylquinolin-8-ol serves as a key building block for the synthesis of more complex molecules, such as o-chloro hydroxy derivatives in pyridine and quinoline. This makes it a valuable compound for researchers and chemists working on the development of novel chemical entities.
Used in Research and Development:
Due to its unique chemical properties, 7-bromo-5-methylquinolin-8-ol is also used in research and development for the exploration of new chemical reactions and the discovery of new compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C10H8BrNO/c1-6-5-8(11)10(13)9-7(6)3-2-4-12-9/h2-5,13H,1H3

Upstream product

• 521-74-4 broxyquinoline 
• 74-88-4 methyl iodide 
• 5541-67-3 5-methyl-8-quinolinol 

Downstream Products

• 90799-56-7 7-chloro-8-hydroxy-5-methylquinoline 

Relevant articles and documents

Bromine-Lithium Exchange on Bromo-8-hydroxyquinolines via Formation of their Sodium Salts.

A short and versatile method is reported for the preparation of 8-hydroxyquinoline derivatives by reaction of n-butyllithium with 5,7-dibromo-8-hydroxyquinoline 2 and 7-bromo-8-hydroxyquinoline 1 as their sodium salts.Thus, bromine-lithium exchange reaction on compound 2, highly regioselective, gave after addition of various electrophiles, 5-substituted 7-bromo-8-hydroxyquinolines 4a-j in moderate to good yields.The same procedure was also applicable to 7-bromo-8-hydroxyquinoline 1 which led to 7-substituted 8-hydroxyquinolines 3a-b.

NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.