718-07-0Relevant articles and documents
Racemization method of chiral N-phenylacetyl amino acid and derivatives thereof
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Paragraph 0056; 0057, (2019/03/28)
The invention belongs to the field of amino acid racemization, and in particular discloses a racemization method of chiral N-phenylacetyl amino acid and derivatives thereof. The method comprises the following steps: heating phenylacetic acid up to 160-180
The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts
Nora, George P.,Miller, Marvin J.,Moellmann, Ute
, p. 3966 - 3970 (2007/10/03)
The structural similarity between β-lactam antibiotics, such as penicillin, and isoxazolidine-3,5-dicarboxylic acids led to the hypothesis that isoxazolidine-3,5-dicarboxylic acids could be effective analogs of β-lactam antibiotics. The syntheses of relevant isoxazolidine-3,5-dicarboxylic acids from acylnitroso Diels-Alder adducts and subsequent biological testing have shown that these first examples are inhibitors of Escherichia coli X580.
Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
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, (2008/06/13)
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer''s disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer''s disease both prophylactically and therapeutically with such pharmaceutical compositions.
