718-43-4

Basic information

• Product Name: N-(3-Chlorophenyl)-1,3,5-triazine-2,4-diamine
• Synonyms: N-(3-Chlorophenyl)-1,3,5-triazine-2,4-diamine;R-37;N2-(3-chlorophenyl)-1,3,5-triazine-2,4-diamine
• CAS NO: 718-43-4
• Molecular Formula: C₉H₈ClN₅
• Molecular Weight: 221.65
• Mol File: 718-43-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 145-146 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 454.9°C at 760 mmHg
• Flash Point: 228.9°C
• Appearance: /
• Density: 1.483g/cm³
• Vapor Pressure: 1.84E-08mmHg at 25°C
• Refractive Index: 1.72
• PKA: 3.51±0.10(Predicted)
• CAS DataBase Reference: N-(3-Chlorophenyl)-1,3,5-triazine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Chlorophenyl)-1,3,5-triazine-2,4-diamine(718-43-4)
• EPA Substance Registry System: N-(3-Chlorophenyl)-1,3,5-triazine-2,4-diamine(718-43-4)

Safety Data

• Hazardous Substances Data: 718-43-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8ClN5/c10-6-2-1-3-7(4-6)14-9-13-5-12-8(11)15-9/h1-5H,(H3,11,12,13,14,15)

Upstream product

• 48144-44-1 m-Chlorophenylbiguanide 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.