71800-36-7

Basic information

• Product Name: LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE
• Synonyms: LYS-(DES-ARG9)-BRADYKININ;LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE;LYSYL-DES-ARG9-BRADYKININ;[LYS0, DES-ARG9]-BRADYKININ;(DES-ARG10)-KALLIDIN;[DES-ARG9,LYS0]-BRADYKININ;H-LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-OH;des-arg(10)-kallidi
• CAS NO: 71800-36-7
• Molecular Formula: C50H73N13O11
• Molecular Weight: 1032.2
• Product Categories: Bradykinin receptor
• Mol File: 71800-36-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.45g/cm3
• Refractive Index: 1.678
• Storage Temp.: −20°C
• CAS DataBase Reference: LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE(CAS DataBase Reference)
• NIST Chemistry Reference: LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE(71800-36-7)
• EPA Substance Registry System: LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE(71800-36-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 71800-36-7(Hazardous Substances Data)

Usage

Uses

[Lys-des-Arg9]-Bradykinin has been used as a B1R agonist to investigate the role of B1R in diabetes-induced secondary hemorrhage.

Biochem/physiol Actions

[Des-Arg10]-kallidin or [Lys-des-Arg9]-Bradykinin is a bradykinin B1 receptor agonist. It strongly upregulates the B1 receptor and is blocked by a specific protein kinase C inhibitor. The upregulation is correlated with the induction of transcription nuclear factor κB (NF-κB). Elevation of Lys-des[Arg9]–bradykinin because of airway inflammation in asthma patients is known to modify the immune responses. It affects the migration and production of interleukin-12 in monocyte-derived dendritic cells.

InChI:InChI=1/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1