71800-49-2Relevant articles and documents
Tetraethylorthosilicate as a mild dehydrating reagent for the synthesis of N-formamides with formic acid
Nishikawa, Yasuhiro,Nakamura, Hidetsugu,Ukai, Norimitsu,Adachi, Wakana,Hara, Osamu
, p. 860 - 863 (2017)
The synthesis of N-formamides with formic acid as a formyl source under mild conditions was achieved using tetraethylorthosilicate (TEOS), a low cost and environmentally benign reagent. The mild conditions in this system enable the formylation of a variety of amino acid derivatives including stereochemically labile phenylglycine ethyl ester with 96% ee. This new protocol could also be applied to simple amines including weakly basic aniline derivatives, giving various primary and secondary formamides.