7181-79-5

Basic information

• Product Name: 1,3,5-Cyclohexanetrione, 2,2,4,4-tetramethyl-
• CAS NO: 7181-79-5
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• Mol File: 7181-79-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,3,5-Cyclohexanetrione, 2,2,4,4-tetramethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Cyclohexanetrione, 2,2,4,4-tetramethyl-(7181-79-5)
• EPA Substance Registry System: 1,3,5-Cyclohexanetrione, 2,2,4,4-tetramethyl-(7181-79-5)

Safety Data

• Hazardous Substances Data: 7181-79-5(Hazardous Substances Data)

Usage

Appearance

Yellow solid

Usage

a. Reagent in chemical reactions
b. Building block for synthesis of other organic compounds

Properties

a. Antioxidant

Applications

a. Production of rubber and plastics
b. Formulation of dyes and pigments
c. Production of pharmaceuticals and specialty chemicals

Medical potential

Studied for treatment of certain types of cancer and other diseases

Upstream product

• 88-03-9 2,4,6-trihydroxytoluene 
• 124-41-4 sodium methylate 
• 74-88-4 methyl iodide 
• 7073-22-5 4-acetyl-5-hydroxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione 
• 4447-64-7 ethyl 2,2,4-trimethyl-3-oxopentanoate 
• 1719-22-8 5-methoxy-2,2,6,6-tetramethyl-cyclohex-4-ene-1,3-dione 
• 10034-85-2 hydrogen iodide 
• 7647-01-0 hydrogenchloride 
• 567-75-9 leptospermone 
• 4463-02-9 2,4-dimethylbenzene-1,3,5-triol 
• 67-56-1 methanol 
• 108-73-6 3,5-dihydroxyphenol 
• 75-36-5 acetyl chloride 
• 127603-32-1 2,2,4-trimethyl 4-ene 3-trimethylsiloxy ethyl pentanoate 

Downstream Products

• 80597-59-7 C-acetylsyncarpic acid 
• 1160560-78-0 C₂₄H₂₆O₃ 
• 1160560-79-1 C₁₈H₂₁BrO₃ 

Relevant articles and documents

Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

A series of novel hybrids of artemisinin (ART) with either a phytormone endoperoxide G factor analogue (GMeP) or chloroquine (CQ) and conjugates of the same compounds with the polyamines (PAs), spermidine (Spd), and homospermidine (Hsd) were synthesized and their antiplasmodial activity was evaluated using the CQ-resistant P. falciparum FcB1/Colombia strain. The ART-GMeP hybrid 5 and compounds 9 and 10 which are conjugates of Spd and Hsd with two molecules of ART and one molecule of GMeP, were the most potent with IC50 values of 2.6, 8.4, and 10.6 nM, respectively. The same compounds also presented the highest selectivity indexes against the primary human fibroblast cell line AB943 ranging from 16 372 for the hybrid 5 to 983 for the conjugate 10 of Hsd.

Ring opening myrtle ketone analogue as well as preparation method and application thereof to antibacterial medicines

The invention discloses a ring opening myrtle ketone analogue as well as a preparation method and application thereof to antibacterial medicines. The structure of the ring opening myrtle ketone analogue is shown in a formula (1) in the specification, wherein in the formula (1), R is H, a C1-C15 straight chain or branched chain or naphthenic base or an aromatic group. The ring opening myrtle ketone analogue has obvious activity of resisting Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Bacillus cereus, B.subtilis, B.thuringiensis or Escherichia coli, so the ring opening myrtle ketone analogue can be used for preparing bacterial infection resistant medicines and is especially applied to preventing and treating clinically common MRSA infectious diseases.

Process for producing 2,2,4,4-tetra-substituted 1,3,5-cyclohexanetriones

Process for the preparation of 2,2,4,4-tetrasubstituted 1,3,5-cyclohexanetriones of the formula I, by reaction of a cyclobutane-1,3-dione of the formula II with an O or N nucleophile and a silylating reagent, and subsequent acetylation and cyclization.