71811-26-2Relevant articles and documents
An M2-V27A channel blocker demonstrates potent in?vitro and in?vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses
Hu, Yanmei,Musharrafieh, Rami,Ma, Chunlong,Zhang, Jiantao,Smee, Donald F.,DeGrado, William F.,Wang, Jun
, p. 45 - 54 (2017/01/25)
Adamantanes such as amantadine (1) and rimantadine (2) are FDA-approved anti-influenza drugs that act by inhibiting the wild-type M2 proton channel from influenza A viruses, thereby inhibiting the uncoating of the virus. Although adamantanes have been suc
Novel 2,5-Disubstituted 1,3-dioxanes and oxazolidines as potential chemoprevention agents and building blocks for organic synthesis
Rueger, Anne J.,Nieger, Martin,Es-Sayed, Maezen,Braese, Stefan
experimental part, p. 3837 - 3846 (2010/09/10)
2,5-Disubstituted 1,3-dioxacycloalkanes have recently been found to be promising lead, compounds that possess potent anti-inflammatory activity and therefore may act as chemoprevention agents. Encouraged by this we have designed and synthesized a new seri
Highly efficient synthesis of enantiomerically enriched 2-hydroxymethylaziridines by enzymatic desymmetrization
Jun, Young Choi,Borch, Richard F.
, p. 215 - 218 (2007/10/03)
(Chemical Equation Presented) Both enantiomers of protected and unprotected 2-hydroxymethylaziridines are efficiently and enantiospecifically synthesized by using a combination of enzymatic and synthetic methods. PPL was used for lipase-catalyzed desymmet