71865-37-7 Usage
Description
DITHIO-BIS-MALEIMIDOETHANE, also known as DTBM, is a homobifunctional crosslinking reagent that is sulfhydryl reactive. It is characterized by a spacer arm of 13.3 angstroms, which allows for the efficient and specific crosslinking of molecules containing sulfhydryl groups.
Uses
Used in Bioconjugation Applications:
DITHIO-BIS-MALEIMIDOETHANE is used as a crosslinking agent for the bioconjugation of molecules with sulfhydryl groups, such as proteins, peptides, and antibodies. Its sulfhydryl reactivity and spacer arm length enable the formation of stable and specific conjugates, which are essential for various research and diagnostic applications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, DITHIO-BIS-MALEIMIDOETHANE is used as a crosslinking agent in the development of drug delivery systems. Its ability to form stable and specific conjugates allows for the efficient delivery of therapeutic agents to target cells and tissues, improving the efficacy and bioavailability of drugs.
Used in Biosensor Development:
DITHIO-BIS-MALEIMIDOETHANE is also used in the development of biosensors, where its sulfhydryl reactivity and spacer arm length enable the immobilization of biologically active molecules onto sensor surfaces. This allows for the sensitive and selective detection of target analytes in various applications, such as environmental monitoring, medical diagnostics, and food safety testing.
Check Digit Verification of cas no
The CAS Registry Mumber 71865-37-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,8,6 and 5 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 71865-37:
(7*7)+(6*1)+(5*8)+(4*6)+(3*5)+(2*3)+(1*7)=147
147 % 10 = 7
So 71865-37-7 is a valid CAS Registry Number.
71865-37-7Relevant articles and documents
Redox-Responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering
Dispinar, Tugba,Van Camp, Wim,De Cock, Liesbeth J.,De Geest, Bruno G.,Du Prez, Filip E.
experimental part, p. 383 - 394 (2012/06/30)
A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering.
