7187-01-1

Basic information

• Product Name: 2-FURANACRYLONITRILE
• Synonyms: B-(2-FURYL)ACRYLONITRILE;2-FURANACRYLONITRILE;2-furanacrylonitrile, mixture of cis and tra;2-Furanacrylonitrile,mixture of cis and trans;3-(2-furyl)-acrylonitrile;2-FURANACRYLONITRILE, 97%, MIXTURE OF CI S AND TRANS;3-(2-Furyl)acrylonitril;3-(2-Furyl)-2-propenenitrile
• CAS NO: 7187-01-1
• Molecular Formula: C7H5NO
• Molecular Weight: 119.12
• EINECS: 230-550-9
• Product Categories: Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 7187-01-1.mol
• Article Data: 34

Chemical Properties

• Melting Point: 38°C
• Boiling Point: 222.38°C (rough estimate)
• Flash Point: 189 °F
• Appearance: /
• Density: 1.086 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.138mmHg at 25°C
• Refractive Index: n20/D 1.583(lit.)
• Merck: 13,4319
• CAS DataBase Reference: 2-FURANACRYLONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FURANACRYLONITRILE(7187-01-1)
• EPA Substance Registry System: 2-FURANACRYLONITRILE(7187-01-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-27-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 7187-01-1(Hazardous Substances Data)

Usage

General Description

2-Furanacrylonitrile is a chemical compound with the molecular formula C6H3NO. It is a colorless to light yellow liquid with a faint, sweet odor. 2-Furanacrylonitrile is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of specialty polymers and resins. Due to its potential to cause skin and eye irritation, as well as respiratory issues, precautions should be taken when handling and using 2-Furanacrylonitrile, such as wearing protective gloves and eye goggles. Additionally, it is important to store and dispose of this chemical in a safe and responsible manner to prevent environmental contamination.

InChI:InChI=1/C7H5NO/c8-5-1-3-7-4-2-6-9-7/h1-4,6H/b3-1+

Upstream product

• 25525-85-3 (2E)-3-(2-furyl)prop-2-enamide 
• 98-01-1 furfural 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 107-14-2 chloroacetonitrile 
• 2181-42-2 trimethylsulphonium iodide 
• 75-05-8 acetonitrile 
• 590-17-0 cyanomethyl bromide 
• 527-69-5 2-furancarbonyl chloride 
• 107-13-1 acrylonitrile 
• 39511-08-5 (E)-3-(2-furanyl)-2-propenal 
• 122-52-1 triethyl phosphite 
• 793706-87-3 (1,1-dimethylethoxy)diphenylsilylacetonitrile 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 98-00-0 (2-furyl)methyl alcohol 

Downstream Products

• 21446-61-7 3-(furan-2-yl)propanenitrile 
• 18873-35-3 (Z)-β-(5-Nitro-fur-2-yl)-acrylonitril 
• 18873-36-4 (E)-β-(5-Nitro-fur-2-yl)-acrylonitril 
• 36878-54-3 (Z)-3-Furan-2-yl-acrylimidic acid methyl ester; hydrochloride 
• 604800-01-3 1-[2-(2-furanyl)vinyl]cyclopropylamine 

Relevant articles and documents

Preparation method of nitrile compound

The present invention belongs to the field of organic synthesis technology, specifically relates to a method for preparing a nitrile compound, aldehyde oxime derivatives as raw materials, adding DPPA and DBU, reacting in an organic solvent, one step to pr

Nickel-Catalyzed Transformation of Alkene-Tethered Oxime Ethers to Nitriles by a Traceless Directing Group Strategy

Nickel-catalyzed transformation of alkene-tethered oxime ethers to nitriles using a traceless directing group strategy has been developed. A series of alkene-tethered oxime ethers derived from benzaldehyde and cinnamyl aldehyde derivatives were converted into the corresponding benzonitriles and cinnamonitriles in 46-98% yields using the nickel catalyst system. Control experiments showed that the alkene group tethered to an oxygen atom on the oximes via one methylene unit plays a key role as a traceless directing group during the catalysis.

Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides to Form Nitriles

A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.