7188-95-6

Basic information

• Product Name: methyl 1-phenyl-1H-pyrazole-3-carboxylate
• Synonyms: methyl 1-phenyl-1H-pyrazole-3-carboxylate
• CAS NO: 7188-95-6
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.2093
• Mol File: 7188-95-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 74-75 °C
• Boiling Point: 316.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: -2.52±0.10(Predicted)
• CAS DataBase Reference: methyl 1-phenyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-phenyl-1H-pyrazole-3-carboxylate(7188-95-6)
• EPA Substance Registry System: methyl 1-phenyl-1H-pyrazole-3-carboxylate(7188-95-6)

Safety Data

• Hazardous Substances Data: 7188-95-6(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 4747-46-0 1-phenyl-1H-pyrazole-3-carboxylic acid 
• 67-56-1 methanol 
• 83959-41-5 1-phenyl-3-trichloromethyl-1H-pyrazole 
• 5535-48-8 PVS 
• 58131-64-9 methyl 2-chloro-2-(2-phenylhydrazono)acetate 
• 74-88-4 methyl iodide 
• 111-34-2 -butyl vinyl ether 
• 591-50-4 iodobenzene 
• 15366-34-4 methyl 1H-pyrazole 3-carboxylate 
• 83124-74-7 4-ethoxy-1,1,1-trichloro-3-buten-2-one 
• 103-03-7 1-phenylsemicarbazide 

Downstream Products

• 4747-46-0 1-phenyl-1H-pyrazole-3-carboxylic acid 
• 7189-08-4 (1-phenyl-1H-pyrazol-3-yl)-methanol 

Relevant articles and documents

COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs

An efficient and regioselective procedure for the synthesis of a series of alkyl(aryl/heteroaryl) substituted 3-trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs, from the cyclocondensation reactions of 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones [CX3C(O)CR2=CR 1(OMe/OEt), where R1 = H, Me, Ph, 2-Furyl; R2 = H; R1-R2 = -C4H8- and X = F, Cl] and 1-phenylsemicarbazide in an acidified alcoholic medium (R 3OH/H2SO4), where R3 = Me, Et, Pri was successfully applied and is described here in detail. 2012 Elsevier Ltd. All rights reserved.

Uncommon aqueous media for nitrilimine cycloadditions. I. Synthetic and mechanistic aspects in the formation of 1-aryl-5-substituted-4,5-dihydropyrazoles

A number of 1-aryl-5-substituted-4,5-dihydropyrazoles 4 have been synthesised by 1,3-dipolar cycloaddition of variously substituted nitrilimines 2 onto the appropriate alkenyl dipolarophiles 3 in aqueous media and in the presence of a surfactant. Under these conditions, uncommon for the large majority of [3 + 2] cycloadditions, the electronic features of both the cycloaddends strongly dictate the reaction outcome. Clean and fast cycloadditions were observed between electron-rich nitrilimines and electron-poor dipolarophiles, while the reversal of the electronic features of the reactants gave poor results. Changes in surfactant concentration leads to some novel mechanistic insights.