7188-96-7

Basic information

• Product Name: 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER;1H-Pyrazole-4-carboxylic acid, 1-phenyl-, methyl ester
• CAS NO: 7188-96-7
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.21
• Mol File: 7188-96-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 163-167 °C(Press: 0.5 Torr)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: -2.63±0.10(Predicted)
• CAS DataBase Reference: 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER(7188-96-7)
• EPA Substance Registry System: 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER(7188-96-7)

Safety Data

• Hazardous Substances Data: 7188-96-7(Hazardous Substances Data)

Usage

Methyl ester derivative

1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER is derived from pyrazole-4-carboxylic acid by attaching a methyl group to the carboxylic acid functional group.

Phenyl group attachment

The compound features a phenyl group (a carbon-based ring structure) attached to the 1-position of the pyrazole ring, which influences its chemical properties and reactivity.

Potential applications

1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER has potential uses in the fields of organic chemistry, medicinal chemistry, and pharmaceutical research.

Building block for synthesis

This compound can be used as a building block for the synthesis of various bioactive compounds and pharmaceutical drugs, making it a valuable component in the development of new therapeutic agents.

Reactivity and properties

The properties and reactivity of 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER make it a useful tool for creating new chemical entities with therapeutic potential, further expanding its applications in the field of chemistry and pharmaceuticals.

Upstream product

• 124-41-4 sodium methylate 
• 80981-29-9 1,3-dimethyluracil-5-carbaldehyde phenylhydrazone 
• 292638-85-8 acrylic acid methyl ester 
• 622-11-7 α-nitroformaldehyde phenylhydrazone 
• 100-63-0 phenylhydrazine 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 1134-50-5 4-carboxy-1-phenylpyrazole 
• 70817-26-4 (1-phenyl-1H-pyrazol-4-yl)methanol 

Relevant articles and documents

Solvent-free and montmorillonite K10-catalyzed domino reactions for the synthesis of pyrazoles with alkynylester as a dual synthon

A highly regioselective, solvent-free and montmorillonite K10 clay-catalyzed domino process with an unprecedented ring-closing C-C bond-formation reaction is described for the synthesis of a new class of 1,3,4-trisubstituted and 1,4-disubstituted pyrazole

1,3-Dipolar Cycloadditions, 87. Contributions to the Chemistry of N-Phenylnitrilimine

The N-phenyl derivative 7 is introduced as the first monosubstituted and interceptible nitrilimine whereas the cycloadditions of disubstituted representatives have been preparatively utilized in the past.Photolysis of 2-phenyltetrazole in the presence of methyl acrylate gives rise to methyl 1-phenyl-2-pyrazoline-5-carboxylate which on further irradiation suffers ring cleavage.The sodium salt of α-nitroformaldehyde phenylhydrazone (15) eliminates NaNO2 in refluxing acetonitrile whereby the intermediate 7 is accepted in situ by acrylic ester, styrene and norbornene.The interaction of methyl acrylate with the anionic precursor 15 furnishes further products.The formal dimer of 7, the 1,4-diphenyl-1,4-dihydro-1,2,4,5-tetrazine, is probably formed by reaction of 7 with 15.

A RING TRANSFORMATION OF URACIL INTO THE PYRAZOLE RING SYSTEM. REINVESTIGATION OF THE REACTION OF 5-FORMYLURACILS WITH HYDRAZINES

Cheng et al. reported that the reaction of 5-formyluracil (1a) with hydrazine hydrate in the presence of acetic acid gave 4-ureidomethylene-1H-5-pyrazolone (3).However, results of our reinvestigation revealed that the Cheng's compound (3) should be 4-urei