71888-21-6

Basic information

• Product Name: N,N-diethyl-p-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)benzamide
• Synonyms: N,N-diethyl-p-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)benzamide
• CAS NO: 71888-21-6
• Molecular Weight: 274.363
• Mol File: 71888-21-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-p-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-p-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)benzamide(71888-21-6)
• EPA Substance Registry System: N,N-diethyl-p-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)benzamide(71888-21-6)

Safety Data

• Hazardous Substances Data: 71888-21-6(Hazardous Substances Data)

Upstream product

• 1571-08-0 methyl 4-formylbenzoate 
• 109-89-7 diethylamine 
• 32664-14-5 2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline 
• 88-10-8 N,N-diethylcarbamyl chloride 

Downstream Products

• 71888-33-0 C₁₆H₂₁⁽²⁾HN₂O₂ 

Relevant articles and documents

Regioselective Functionalization of Ester-, Amide-, Carbonate-, and Carbamate-Substituted 2-Phenyl-2-oxazolines with Mixed Lithium-Magnesium Amides

We have prepared novel highly functionalized benzene derivatives by regioselective metalation of ester-, amide-, carbamate-, and carbonate-substituted 2-phenyl-2-oxazolines with mixed lithium-magnesium amides followed by reaction with different electrophiles. While a complementary metalation site can be accessed by using different bases, steric and electronic effects promoted by the aromatic ring substituents also play an important role in reaction regioselectivity. Computational calculations of the aromatic hydrogen pKa values have helped us to rationalize the metalation preference by the complex-induced proximity effect concept.