719-86-8

Basic information

• Product Name: 2,4-Pyrrolidinedione, 3-acetyl-1-phenyl-
• Synonyms: 2,4-Pyrrolidinedione, 3-acetyl-1-phenyl-;3-acetyl-1-phenyl-pyrrolidine-2,4-dione
• CAS NO: 719-86-8
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.22
• EINECS: 421-600-2
• Mol File: 719-86-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Pyrrolidinedione, 3-acetyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Pyrrolidinedione, 3-acetyl-1-phenyl-(719-86-8)
• EPA Substance Registry System: 2,4-Pyrrolidinedione, 3-acetyl-1-phenyl-(719-86-8)

Safety Data

• Hazard Codes: Xn,N
• Statements: 48/22-51/53
• Safety Statements: 22-36/37-61
• Hazardous Substances Data: 719-86-8(Hazardous Substances Data)

Usage

General Description

3-Acetyl-1-phenyl-2,4-pyrrolidinedione is a chemical substance with the molecular formula C12H11NO3. It is derived from the fusion of a 2,4-pyrrolidinedione ring and a phenyl ring, containing an acetyl group. The phenyl and acetyl substituents are important factors in determining the chemical and physical properties of the substance, including reactivity and solubility. It is often used in various chemical research and synthetic applications. Further specifics, including its hazards, safety measures, and more detailed properties, may depend on its exact form or any additional substances it is mixed with.

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 2216-92-4 N-phenylglycine ethyl ester 

Relevant articles and documents

Novel pyrazole fused heterocyclic ligands: Synthesis, characterization, DNA binding/cleavage activity and anti-BVDV activity

A series of novel pyrazole fused heterocyclic derivatives were synthesized via a two-step procedure or a one-pot two step method, and their catalytic DNA cleavage abilities and anti-BVDV activities were also evaluated. The results obtained indicated that compounds 3b-3c could catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) to nicked DNA under physiological conditions with high yields via a hydrolytic mechanism. The studies on anti-viral activities against bovine viral diarrhea virus (BVDV) demonstrated that some of the pyrazole derivatives showed pronounced anti-BVDV activity with interesting EC50 values and no significant cytotoxicity. Among them, compound 3l showed the highest antiviral activity (EC50 = 0.12 μmol/L) and was 10 fold more than that of the positive control ribavirin (EC50 = 1.3 μmol/L), which provided a potential candidate for the development of anti-BVDV agents.