71922-04-8

Basic information

• Product Name: Proline, 1-nitroso-, methyl ester (9CI)
• Synonyms: Proline, 1-nitroso-, methyl ester (9CI)
• CAS NO: 71922-04-8
• Molecular Formula: C₆H₁₀N₂O₃
• Molecular Weight: 158.1552
• Product Categories: PYRROLE
• Mol File: 71922-04-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Proline, 1-nitroso-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Proline, 1-nitroso-, methyl ester (9CI)(71922-04-8)
• EPA Substance Registry System: Proline, 1-nitroso-, methyl ester (9CI)(71922-04-8)

Safety Data

• Hazardous Substances Data: 71922-04-8(Hazardous Substances Data)

Upstream product

• 43041-12-9 methyl pyrrolidine-2-carboxylate 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 67-56-1 methanol 
• 7519-36-0 nitrosoproline 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 220060-08-2 (R)-2-methylpyrrolidine-2-carboxylic acid methyl ester hydrochloride 
• 104-15-4 toluene-4-sulfonic acid 
• 147-85-3 L-proline 

Downstream Products

• 604003-91-0 (S)-1-aminopyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Substrate promiscuity of ortho-naphthoquinone catalyst: Catalytic aerobic amine oxidation protocols to deaminative cross-coupling and n-nitrosation

ortho-Naphthoquinone-based organocatalysts have been identified as versatile aerobic oxidation catalysts. Primary amines were readily cross-coupled with primary nitroalkanes via deaminative pathway to give nitroalkene derivatives in good to excellent yields. Secondary and tertiary amines were inert to ortho-naphthoquinone catalysts; however, secondary nitroalkanes were readily converted by ortho-naphthoquinone catalysts to the corresponding nitrite species that in situ oxidized the amines to the corresponding N-nitroso compounds. Without using harsh oxidants in a stoichiometric amount, the present catalytic aerobic oxidation protocol utilizes the substrate promiscuity feature to provide a facile access to amine oxidation products under mild reaction conditions.

DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE AND PHARMACEUTICALS CONTAINING THE SAME

The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Diversity-oriented synthesis of a drug-like system displaying the distinctive N→C=O interaction

(Chemical Equation Presented) This study describes the syntheses and characterization of two hydrazino ureas. These fold into a six-membered ring by virtue of the infrequently observed δ+N→C=O δ- interaction when solvated by polar pr