71955-53-8

Basic information

• Product Name: Benzamide, 2,6-dimethoxy-N,N-dimethyl-
• CAS NO: 71955-53-8
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Mol File: 71955-53-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzamide, 2,6-dimethoxy-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2,6-dimethoxy-N,N-dimethyl-(71955-53-8)
• EPA Substance Registry System: Benzamide, 2,6-dimethoxy-N,N-dimethyl-(71955-53-8)

Safety Data

• Hazardous Substances Data: 71955-53-8(Hazardous Substances Data)

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 1989-53-3 2,6-dimethoxybenzoyl chloride 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 125700-67-6 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 
• 124-40-3 dimethyl amine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 60237-95-8 2,6-dihydroxy-benzoic acid dimethylamide 

Relevant articles and documents

POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides

Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.

Pd(PPh3)4 catalyzed amide compound synthesis method

The invention relates to a Pd(PPh3)4 catalyzed amide compound synthesis method. The synthesis method takes carboxylic acid as the substrate, and adopts N-substituted formamide as the amine source to synthesize an amide compound under the catalysis of Pd(PPh3)4. The method is widely applicable to substrates with different functional groups. The amide compound efficiently constructed by the invention is an important skeleton of many organic molecules, drugs, peptides, bioactive molecules and natural products. The synthesis method provided by the invention provides a widely applicable preparation method for synthesis of the compounds.

Beyond directed ortho metalation: Ru-catalyzed CAr-O activation/cross-coupling reaction by amide chelation

Disclosed is a new, catalytic, and general methodology for the chemical synthesis of biaryl, heterobiaryl, and polyaryl molecules by the cross-coupling of o-methoxybenzamides with aryl boroneopentylates. The reaction is based on the activation of the unreactive C-OMe bond by the proximate amide directing group using catalytic RuH2(CO)(PPh3)3 conditions. A one-step, base-free coupling process is thereby established that has the potential to supersede the useful two-step directed ortho metalation/cross- coupling reaction involving cryogenic temperature and strong base conditions. High regioselectivity, orthogonality with the Suzuki-Miyaura reaction, operational simplicity, minimum waste, and convenient scale-up make these reactions suitable for industrial applications.