71997-32-5 Usage
Description
3'-Deoxyadenosine 5'-triphosphate sodium salt, also known as Cordycepin 5'-triphosphate sodium salt, is a toxic derivative of the cytotoxic adenosine analog, Cordycepin (3'-deoxyadenosine), which is a bioactive agent extracted from Cordyceps militaris. It plays a significant role in various biological processes and serves as a crucial compound in research and pharmaceutical applications.
Uses
Used in Research Applications:
3'-Deoxyadenosine 5'-triphosphate sodium salt is used as a transcriptional inhibitor in RNA decay assays. It inhibits polyadenylation in HEK293T cells before harvesting for in vitro interaction studies through co-immunoprecipitation (co-IPs).
Used in Polymerase Inhibition:
In in vitro assays, 3'-Deoxyadenosine 5'-triphosphate sodium salt is used as a positive control for polymerase inhibition, showcasing its ability to interfere with the activity of polymerases, which are essential enzymes in the process of DNA replication and transcription.
Used as a Precursor in Pharmaceutical Production:
3'-Deoxyadenosine 5'-triphosphate sodium salt is utilized as a precursor to produce Cordycepin monophosphate, a compound with potential therapeutic applications in various industries.
Biochem/physiol Actions
Cordycepin exhibits various metabolic effects by activating AMP-activated protein kinase (AMPK) in humans. Cordycepin triphosphate inhibits picornavirus polymerase-specific RNA synthesis by blocking in vitro [3H]GMP incorporation. It also retards cell growth by inhibiting RNA synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 71997-32-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,9,9 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 71997-32:
(7*7)+(6*1)+(5*9)+(4*9)+(3*7)+(2*3)+(1*2)=165
165 % 10 = 5
So 71997-32-5 is a valid CAS Registry Number.
