72000-18-1

Basic information

• Product Name: ETHYL 2-(2-OXO-2H-CHROMEN-7-YLOXY)ACETATE
• Synonyms: ETHYL 2-(2-OXO-2H-CHROMEN-7-YLOXY)ACETATE;(2-OXO-2H-CHROMEN-7-YLOXY)-ACETIC ACID ETHYL ESTER
• CAS NO: 72000-18-1
• Molecular Formula: C₁₃H₁₂O₅
• Molecular Weight: 248.23
• Mol File: 72000-18-1.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2-(2-OXO-2H-CHROMEN-7-YLOXY)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(2-OXO-2H-CHROMEN-7-YLOXY)ACETATE(72000-18-1)
• EPA Substance Registry System: ETHYL 2-(2-OXO-2H-CHROMEN-7-YLOXY)ACETATE(72000-18-1)

Safety Data

• Hazardous Substances Data: 72000-18-1(Hazardous Substances Data)

Usage

General Description

ETHYL 2-(2-OXO-2H-CHROMEN-7-YLOXY)ACETATE, also known as ethyl 7-oxo-2-oxochromen-2-yl acetate, is a chemical compound with the molecular formula C13H10O5. It is a derivative of chromone, a class of organic compounds known for their wide range of biological activities. ETHYL 2-(2-OXO-2H-CHROMEN-7-YLOXY)ACETATE has been studied for its potential pharmacological properties, including antioxidant, anti-inflammatory, and anticancer activities. It is commonly used in chemical research and drug discovery as a starting material for the synthesis of other bioactive compounds. Additionally, it has industrial applications in the production of fragrances and flavoring agents due to its aromatic properties.

Upstream product

• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 105-36-2 ethyl bromoacetate 
• 623-48-3 ethyl iodoacetae 

Downstream Products

• 126424-85-9 2-[(2-oxo-2H-chromen-7-yl)oxy]acetic acid 
• 301206-07-5 N-(6-amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(2-oxo-2H-chromen-7-yloxy)-acetamide 
• 1332326-37-0 7-[(5-(phenylamino)-1,3,4-thiazol-2-yl)methoxy]-2H-chromen-2-one 
• 1332326-38-1 7-[(4-phenyl-5-thioxo-4,5-dihydro-1H-1,3,4-triazol-3-yl)methoxy]-2H-chromen-2-one 
• 902304-71-6 7-(2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy)-2H-chromen-2-one 
• 1180933-19-0 7-(2-(4-(2-fluorophenyl)piperazin-1-yl)-2-oxoethoxy)-2H-chromen-2-one 
• 1618668-25-9 7-(2-(4-(3,4-dichlorophenyl)piperazin-1-yl)-2-oxoethoxy)-2H-chromen-2-one 
• 937874-17-4 7-(2-(4-benzylpiperidin-1-yl)-2-oxoethoxy)-2H-chromen-2-one 
• 900871-24-1 N-(1-benzylpiperidin-4-yl)-2-((2-oxo-2H-chromen-7-yl)oxy)acetamide 
• 937874-35-6 N-(3,4-dimethoxyphenethyl)-2-((2-oxo-2H-chromen-7-yl)oxy)acetamide 

Relevant articles and documents

Synthesis, in vitro evaluation and molecular docking studies of novel coumarin-isatin derivatives as α-glucosidase inhibitors

This study synthesized a series of novel coumarin-isatin derivatives and evaluated them for α-glucosidase inhibitory activity. The majority of the screened compounds exhibited excellent inhibition activities with IC50 values of 2.56?±?0.08–268.79?±?3.04?μm, when compared to acarbose. Among the newly derivatives, compound 5p was found to be the most active compound in the library of coumarin-isatin derivatives. Furthermore, enzyme kinetic studies showed that compound 5p is a non-competitive inhibitor with a Ki of 2.14?μm. Molecular docking analysis revealed the existence of hydrophobic and hydrogen interactions between compound 5p and the active site of α-glucosidase. Our results indicate that coumarin-isatin derivatives as a new class of α-glucosidase inhibitors.

Synthesis and Biological Evaluation of Substituted Indole and Its Analogs as Influenza A Virus Inhibitors

Influenza A virus (IAV), a highly pathogenic virus to human beings, is most susceptible to mutation and thus causes rapid, severe global pandemics resulting in millions of fatalities worldwide. Since resistance to the existing anti-influenza drugs is developing, innovative inhibitors with a different mode of action are urgently needed. The lead compound 6092B-E5 has proven to be an effective antiviral reagent in our previous work. Using the principles of substitution and bioisosterism of the indole ring, six series of novel anti-IAV target products were designed, synthesized and evaluated for their antiviral effect in this work. Compounds D1, D3, D9, G1, G3, G12 and G23 were identified as promising anti-IAV candidates with excellent anti-IAV efficacy (IC50 values of 3.06–5.77 μm) and low cytotoxicity (CC50 values up to and beyond 100 μm). This work represents a successful application of the substitution and bioisosteric replacement strategy for the discovery of novel antiviral molecules that can be used for further structural optimization.

Synthesis and anti-acetylcholinesterase activity of N-[(indolyl)ethyl)- coumarin-yloxy)]alkanamides

Novel coumarin-tryptamine systems attached through a linker were synthesised and evaluated in vitro against acetylcholinesterase by the classical Ellman's test.