72013-81-1

Basic information

• Product Name: ethyl 1-hydroxycyclododecaneacetate
• Synonyms: ethyl 1-hydroxycyclododecaneacetate;1-Hydroxycyclododecaneacetic acid ethyl ester
• CAS NO: 72013-81-1
• Molecular Formula: C₁₆H₃₀O₃
• Molecular Weight: 270.4076
• EINECS: 276-287-3
• Mol File: 72013-81-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 371.4 °C at 760 mmHg
• Flash Point: 143.4 °C
• Appearance: /
• Density: 0.957 g/cm³
• Vapor Pressure: 4.96E-07mmHg at 25°C
• Refractive Index: 1.459
• CAS DataBase Reference: ethyl 1-hydroxycyclododecaneacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-hydroxycyclododecaneacetate(72013-81-1)
• EPA Substance Registry System: ethyl 1-hydroxycyclododecaneacetate(72013-81-1)

Safety Data

• Hazardous Substances Data: 72013-81-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H30O3/c1-2-19-15(17)14-16(18)12-10-8-6-4-3-5-7-9-11-13-16/h18H,2-14H2,1H3

Upstream product

• 830-13-7 cyclododecanone 
• 623-48-3 ethyl iodoacetae 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Relevant articles and documents

Reformatsky reaction of α-chloroesters with carbonyl compounds with commercially available zinc

The condensation of α-chloroesters with aliphatic as well as aromatic ketones with commercially available zinc without any external metal additives is described.

Carbon-Carbon Bond-Forming Reactions Using Cerium Metal or Organocerium(III) Reagents

Carbon-carbon bond-forming reactions using cerium metal or organocerium(III) reagents have been investigated.Cerium amalgam is an effective reagent for the chemoselective preparation of homoallylic alcohols from allyl halides and carbonyl compounds.These same reagent can also be satisfactorily employed for the Reformatsky-type reaction of α-halo esters with carbonyl compounds.It has been shown that organocerium(III) reagents are conveniently generated by the reaction of organolithiums with cerium(III)iodide or cerium(III)chloride.The reagents are less basic thanorganolithiums or Grignard reagents, and they react cleanly at -78 to -65 deg C with various carbonyl compounds to afford the addition products in high yields, even though the substrates are susceptible to enolization or metal-halogen exchange with simple organolithiums.The same reagents react also with α,β-unsaturated compounds to yield 1,2-addition products in high selectivity.