7205-80-3

Basic information

• Product Name: 4-Chlorophenyl ethyl sulfone
• Synonyms: 4-Chlorophenyl ethyl sulfone;1-Chloro-4-(ethylsulphonyl)benzene;4-Ethylsulfonylchlorobenzene;Benzene,1-chloro-4-(ethylsulfonyl)-;Ethyl(4-chlorophenyl) sulfone;1-Chloro-4-ethanesulfonylbenzene
• CAS NO: 7205-80-3
• Molecular Formula: C₈H₉ClO₂S
• Molecular Weight: 204.67
• EINECS: 230-577-6
• Mol File: 7205-80-3.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 340.3 °C at 760 mmHg
• Flash Point: 159.6 °C
• Appearance: /
• Density: 1.281 g/cm³
• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Chlorophenyl ethyl sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorophenyl ethyl sulfone(7205-80-3)
• EPA Substance Registry System: 4-Chlorophenyl ethyl sulfone(7205-80-3)

Safety Data

• Hazardous Substances Data: 7205-80-3(Hazardous Substances Data)

Usage

General Description

4-Chlorophenyl ethyl sulfone is a chemical compound that falls under the categorization of organosulfur compounds. 4-Chlorophenyl ethyl sulfone is primarily made of carbon, hydrogen, chlorine, and sulfur atoms, indicating its classification as an organic chemical. 4-Chlorophenyl ethyl sulfone, due to its structural configuration, is a sulfone, characterized by the presence of a sulfonyl functional group. It has specific applications in various chemical reactions, serving as a reactant or an intermediate in the synthesis process. Its specific use varies depending on the chemical or pharmaceutical industry, and like all chemicals, it should be handled with care to prevent harmful exposure or reactions.

InChI:InChI=1/C8H9ClO2S/c1-2-12(10,11)8-5-3-7(9)4-6-8/h3-6H,2H2,1H3

Upstream product

• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 75-03-6 ethyl iodide 
• 5120-72-9 p-chlorophenyl ethyl sulfide 
• 100249-46-5 (4-Chlor-Δ^3.4-cyclohexenyl)-aethyl-sulfon 
• 74-96-4 ethyl bromide 
• 64-67-5 diethyl sulfate 
• 108-90-7 chlorobenzene 
• 594-44-5 Ethanesulfonyl chloride 
• 106-39-8 bromochlorobenzene 
• 108-10-1 4-methyl-2-pentanone 
• 78-38-6 ethylphosphonic acid diethyl ester 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 21700-74-3 (p-chlorophenyl)triethoxysilane 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 75259-29-9 2-(4-Chloro-benzenesulfonyl)-1,1-diphenyl-propan-1-ol 
• 75259-49-3 1-[1-(4-Chloro-benzenesulfonyl)-ethyl]-cyclohexanol 
• 75259-48-2 2-(4-Chloro-benzenesulfonyl)-1-phenyl-propan-1-ol 
• 2924-67-6 fluoresone 
• 92244-16-1 4-ethanesulfonyl-N,N-dimethyl-aniline 
• 7205-83-6 4-chloro-1-(propane-2-sulphonyl)benzene 
• 74159-80-1 1-chloro-4-(ethylsulphonyl)-2-nitrobenzene 
• 43115-40-8 2-amino-4-(ethylsulfonyl)phenol 
• 84996-11-2 4-(ethylsulfonyl)-2-nitro-phenol 

Relevant articles and documents

Iodine-Mediated Sulfenylation of Imidazo[1,2- a ]pyridines with Ethyl Arylsulfinates

A simple iodine-mediated approach is reported for the synthesis of sulfenylated imidazo[1,2- a ]pyridines through the reaction of imidazo[1,2- a ]pyridines with ethyl arylsulfinates under mild conditions. The reaction scope was investigated, and a plausible mechanism is proposed to elucidate the reaction process and activation mode. The results indicate that ethyl sulfinates are efficient sulfur sources for the construction of C-S bonds.

Design, synthesis and anticancer/antiestrogenic activities of novel indole-benzimidazoles

Indole-benzimidazoles have recently gained attention due to their antiproliferative and antiestrogenic effects. However, their structural similarities and molecular mechanisms shared with selective estrogen receptor modulators (SERMs) have not yet been investigated. In this study, we synthesized novel ethylsulfonyl indole-benzimidazole derivatives by substituting the first (R1) and fifth (R2) positions of benzimidazole and indole groups, respectively. Subsequently, we performed 1H NMR, 13C NMR, and Mass spectral and in silico docking analyses, and anticancer activity screening studies of these novel indole-benzimidazoles. The antiproliferative effects of indole-benzimidazoles were found to be more similar between the estrogen (E2) responsive cell lines MCF-7 and HEPG2 in comparison to the Estrogen Receptor negative (ER-) cell line MDA-MB-231. R1:p-fluorobenzyl group members were selected as lead compounds for their potent anticancer effects and moderate structural affinity to ER. Microarray expression profiling and gene enrichment analyses (GSEA) of the selected compounds (R1:p-fluorobenzyl: 48, 49, 50, 51; R1:3,4-difluorobenzyl: 53) helped determine the similarly modulated cellular signaling pathways among derivatives. Moreover, we identified known compounds that have significantly similar gene signatures to that of 51 via queries performed in LINCS database; and further transcriptomics comparisons were made using public GEO datasets (GSE35428, GSE7765, GSE62673). Our results strongly demonstrate that these novel indole-benzimidazoles can modulate ER target gene expression as well as dioxin-mediated aryl hydrocarbon receptor and amino acid deprivation-mediated integrated stress response signaling in a dose-dependent manner.

Synthesis of Aromatic Sulfones from SO2 and Organosilanes Under Metal-free Conditions

The conversion of SO2 into arylsulfones under metal-free conditions was achieved for the first time by reacting SO2 with (hetero)arylsilanes and alkylhalides in the presence of a fluoride source. The mechanism of this transformation was elucidated based on DFT calculations, which highlight the influence of SO2 in promoting C?Si bond cleavage.