720684-10-6Relevant articles and documents
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
Li, Jin,Bertinato, Peter,Cheng, Hengmiao,Cole, Bridget M.,Bronk, Brian S.,Jaynes, Burton H.,Hickman, Anne,Haven, Michelle L.,Kolosko, Nicole L.,Barry, Chris J.,Manion, Tara B.
, p. 3039 - 3042 (2008/09/20)
We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.