72084-13-0

Basic information

• Product Name: 2-Phenoxybenzamide
• Synonyms: 2-Phenoxybenzamide;o-Phenoxybenzamide
• CAS NO: 72084-13-0
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.23
• Mol File: 72084-13-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Phenoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenoxybenzamide(72084-13-0)
• EPA Substance Registry System: 2-Phenoxybenzamide(72084-13-0)

Safety Data

• Hazardous Substances Data: 72084-13-0(Hazardous Substances Data)

Upstream product

• 21905-56-6 methyl 2-phenoxybenzoate 
• 6476-32-0 o-phenoxybenzonitrile 
• 41755-76-4 ethyl 2-phenoxybenzoate 
• 2243-42-7 2-phenoxybenzoic acid 
• 40501-36-8 2-phenoxybenzoyl chloride 
• 445-28-3 2-fluorobenzamide 
• 108-95-2 phenol 
• 101-84-8 diphenylether 
• 62256-41-1 2-(4-nitrophenoxy)benzaldehyde 
• 19434-34-5 2-(phenoxy)benzaldehyde 

Downstream Products

• 6476-32-0 o-phenoxybenzonitrile 
• 257-07-8 dibenz[b,f][1,4]oxazepine 
• 90-47-1 xanth-9-one 
• 7664-41-7 ammonia 
• 2243-42-7 2-phenoxybenzoic acid 

Relevant articles and documents

Base-promoted nucleophilic fluoroarenes substitution of C–F bonds

With the use of KOH/DMSO as the superbase medium, the nucleophilic fluoroarene substitution for C–F bonds is presented. The transformation proceeds smoothly with the use of fluoroarenes bearing not only electron-withdrawing group, but also electron-donating group and a variety of nucleophiles such as alcohols, phenols, amines, amides and nitrogen-heterocyclic compounds. The double nucleophilic substitution using ortho-difluoroarenes and nucleophiles bearing ortho-dinucleophilic groups results in the formation of 2,3-dihydro-1,4-benzodioxins, dibenzo[b,e][1,4]dioxins and 10H-phenoxazines in moderate to good yields.

Synthesis of diaryl ethers, diaryl thioethers, and diarylamines mediated by potassium fluoride-alumina and 18-crown-6: Expansion of scope and utility

An efficient alternative to the Ullmann ether synthesis of diaryl ethers, diaryl thioethers, and diarylamines involving the S(N)Ar addition of a phenol, thiophenol, or aniline to an appropriate aryl halide, mediated by potassium-fluoride alumina and 18-crown-6 in acetonitrile or DMSO, is described. Expansion of the reaction conditions to include DMSO as solvent has resulted in a far greater range of substitution patterns permitted on the electrophile. For example, it was found that electronically unfavorable 3- chlorobenzonitrile could be condensed with 3-methoxyphenol to form the corresponding diaryl ether in 66% yield, a combination not normally amenable to Ullmann coupling. Electron-withdrawing groups present on the electrophile may be as diverse as nitro, cyano, formyl, acetyl, ester, amide, and even aryl. The method features a simple reaction procedure that provides products in generally good to excellent purified yields.