72093-03-9

Basic information

• Product Name: 3-CHLORO-2-METHYLPYRIDINE
• Synonyms: 3-CHLORO-2-PICOLINE;3-CHLORO-2-METHYLPYRIDINE;Pyridine, 3-chloro-2-methyl-;Pyridine, 3-chloro-2-methyl- (9CI)
• CAS NO: 72093-03-9
• Molecular Formula: C₆H₆ClN
• Molecular Weight: 127.57
• EINECS: -0
• Product Categories: pharmacetical;Halides;Pyridines
• Mol File: 72093-03-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 156.5 °C at 760 mmHg
• Flash Point: 60.2 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 3.72mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.67±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-2-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-METHYLPYRIDINE(72093-03-9)
• EPA Substance Registry System: 3-CHLORO-2-METHYLPYRIDINE(72093-03-9)

Safety Data

• Hazardous Substances Data: 72093-03-9(Hazardous Substances Data)

Usage

General Description

3-Chloro-2-methylpyridine is a chemical compound with the molecular formula C6H6ClN. It is a chlorinated derivative of 2-methylpyridine and belongs to the class of organic compounds known as pyridines and derivatives. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the manufacturing of various chemicals and as a building block in organic synthesis. 3-Chloro-2-methylpyridine is a colorless to yellowish liquid with a strong, pungent odor and is flammable, making it important to handle and store with caution.

InChI:InChI=1/C6H6ClN/c1-5-6(7)3-2-4-8-5/h2-4H,1H3

Upstream product

• 137778-19-9 3-chloro-2-methyl-6-pyridinecarboxylic acid 
• 626-60-8 3-Chloropyridine 
• 3512-76-3 3-chloro-2,6-dimethylpyridine N-oxide 
• 137778-17-7 3-chloro-6-formyl-2-methylpyridine 
• 137778-09-7 3-chloro-2-methyl-6-pyridylmethanol 
• 2402-77-9 2,3-dichloro-pyridine 
• 75-16-1 methylmagnesium bromide 
• 3430-10-2 2-methyl-3-pyridinamine 

Downstream Products

• 57266-69-0 3-chloropyridine-2-carboxylic acid 
• 60588-81-0 3-chloro-2-hydroxy-methyl-pyridine 
• 206181-90-0 3-chloropyridine-2-carboxaldehyde 
• 1217744-61-0 3-((3-chloropyridin-2-yl)methyl)-5-methylcyclohexanone 
• 1217744-62-1 (3-((3-chloropyridin-2-yl)methyl)-5-methylcyclohex-1-enyloxy)trimethylsilane 

Relevant articles and documents

A chloro pyridine and its derivatives synthetic method

The invention discloses a method for synthesizing chloropyridines and derivatives thereof and belongs to the field of fine chemical industry. According to the method, aminopyridine and derivatives thereof undergo a reaction to generate chloropyridines and derivatives thereof. The method is characterized in that phosphorus trichloride, phosphorus oxychloride or thionyl chloride and nitric acid are added into a solution of aminopyridine and the derivatives of aminopyridine, and chloropyridines and derivatives of chloropyridines can be obtained by stirring and reaction. The method has the advantages of being simple to operate, high in yield and less in three wastes.

Nucleophilic addition to 3-substituted pyridinium salts: Expedient syntheses of (-)-L-733,061 and (-)-CP-99,994

(Chemical Equation Presented) The addition of nucleophiles to 3-substituted pyridinium salts prepared from N-methylbenzamide and various pyridines has been investigated. Good to excellent regioselectivities favoring the 2,3-disubstituted 1,2-dihydropyridines were observed. The resulting 1,2-dihydropyridines led to the corresponding 2,3-disubstituted pyridines upon treatment with Mn(OAc)3/NaIO4. This methodology was also successfully applied to the enantioselective syntheses of (-)-L-733,061 and (-)-CP-99,994, two members of a new class of highly potent, nonpeptide, Substance P antagonists.