721-00-6

Basic information

• Product Name: 6-Nitro-1,3-benzodioxole-5-carboxylic acid methyl ester
• Synonyms: 6-Nitro-1,3-benzodioxole-5-carboxylic acid methyl ester;methyl 6-nitro-1,3-benzodioxole-5-carboxylate;6-Nitro-benzo[1,3]dioxole-5-carboxylic acid methyl ester
• CAS NO: 721-00-6
• Molecular Formula: C₉H₇NO₆
• Molecular Weight: 225.155
• Mol File: 721-00-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 345.5°Cat760mmHg
• Flash Point: 168.1°C
• Appearance: /
• Density: 1.497g/cm³
• Vapor Pressure: 6.12E-05mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 6-Nitro-1,3-benzodioxole-5-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Nitro-1,3-benzodioxole-5-carboxylic acid methyl ester(721-00-6)
• EPA Substance Registry System: 6-Nitro-1,3-benzodioxole-5-carboxylic acid methyl ester(721-00-6)

Safety Data

• Hazardous Substances Data: 721-00-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H7NO6/c1-14-9(11)5-2-7-8(16-4-15-7)3-6(5)10(12)13/h2-3H,4H2,1H3

Upstream product

• 326-56-7 methyl 3,4-methylenedioxybenzoate 
• 67-56-1 methanol 
• 716-32-5 6-nitrobenzo[d][1,3]dioxole-5-carboxylic acid 
• 74-88-4 methyl iodide 
• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 120-57-0 piperonal 
• 94-53-1 Piperonylic acid 

Downstream Products

• 40680-63-5 methyl 6-aminobenzo[d][1,3]dioxole-5-carboxylate 
• 20332-16-5 4,5-methylenedioxyanthranilic acid 
• 101423-26-1 6-(4-chloro-benzoylamino)-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 101422-72-4 6-(4-bromo-benzoylamino)-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 101890-89-5 6-(3,4,5-trimethoxy-benzoylamino)-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 110152-88-0 7-amino-6-(3,4,5-trimethoxy-phenyl)-7H-[1,3]dioxolo[4,5-g]quinazolin-8-one 
• 116605-08-4 7-amino-6-(4,4'-dichloro-benzhydryl)-7H-[1,3]dioxolo[4,5-g]quinazolin-8-one 
• 102545-60-8 6-[2,2-bis-(4-chloro-phenyl)-acetylamino]-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 1266868-75-0 ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(3'-chloro-4'-fluorophenyl)amine hydrochloride 
• 1266869-09-3 ([1,3]dioxolo[4,5-g]quinazolin-8-yl)-(4'-bromo-2'-fluorophenyl)amine hydrochloride 
• 1256394-35-0 4-(N-methyl-3-chloro-4-fluoroanilino)-6,7-methylenedioxyquinazoline 
• 1256394-36-1 4-(N-methyl-4-bromo-2-fluoroanilino)-6,7-methylenedioxyquinazoline 
• 72700-23-3 8-chloro-[1,3]dioxolo[4,5-g]quinazoline 
• 20197-55-1 6,8-dichloro-2H-[1,3]dioxolo[4,5-g]quinazoline 

Relevant articles and documents

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The invention discloses a tricyclic compound as a PI3K/mTOR inhibitor. The tricyclic compound is a compound with the general formula (I) in the specification, wherein Ar is selected from aryl or heteroaryl; X, Y and Z are independently selected from O, CR2R3 and NR4 respectively; Q is selected from O, CR2R3 and NR4 or does not exists; R1 represents C1-C6 alkyl; n is selected from integers from 0 to 4; when n is more than or equal to 2, two R1 and a morpholine cycle can be combined into a combined cycle, a bridge cycle or a spiral cycle; R2 and R3 are selected from hydrogen and C1-C6 alkyl; R4 is selected from hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, heterocyclic radical, acyl and sulfonyl. The invention further discloses a perpetration method of the compound with the general formula (I) as well as a pharmaceutical composition and application of the compound with the general formula (I).