7216-42-4

Basic information

• Product Name: 4-PYRIDINECARBOXALDEHYDE N-OXIDE
• Synonyms: 4-PYRIDINECARBOXALDEHYDE N-OXIDE;isonicotinaldehyde 1-oxide;4-Pyridinecarbaldehyde 1-oxide;Einecs 230-602-0;4-Pyridinecarboxaldehyde, 1-oxide;4-Pyridinecarboxaldehyde N-oxide 97%;1-oxidopyridin-1-ium-4-carbaldehyde;4-formylpyridine 1-oxide
• CAS NO: 7216-42-4
• Molecular Formula: C₆H₅NO₂
• Molecular Weight: 123.11
• EINECS: 230-602-0
• Product Categories: Heterocyclic Compounds;C6;Heterocyclic Building Blocks;Pyridines;Aldehydes;Building Blocks;C1 to C6;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 7216-42-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 150-152 °C(lit.)
• Boiling Point: 367.7 °C at 760 mmHg
• Flash Point: 176.2 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 1.35E-05mmHg at 25°C
• Refractive Index: 1.542
• Solubility: methylene chloride: soluble25mg/mL, clear, colorless to yellow
• CAS DataBase Reference: 4-PYRIDINECARBOXALDEHYDE N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDINECARBOXALDEHYDE N-OXIDE(7216-42-4)
• EPA Substance Registry System: 4-PYRIDINECARBOXALDEHYDE N-OXIDE(7216-42-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 7216-42-4(Hazardous Substances Data)

Usage

Description

4-PYRIDINECARBOXALDEHYDE N-OXIDE is an organic compound that serves as an impurity in Donepezil (D531750), a nootropic drug. It is characterized by its aldehyde and N-oxide functional groups, which contribute to its chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
4-PYRIDINECARBOXALDEHYDE N-OXIDE is used as an impurity in the production of Donepezil, a nootropic drug. It plays a role in the synthesis process, contributing to the overall effectiveness of the medication.
Used in Enzyme Inhibition:
4-PYRIDINECARBOXALDEHYDE N-OXIDE is used as an inhibitor of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. By inhibiting this enzyme, it can help maintain higher levels of acetylcholine in the brain, which may improve cognitive function and memory.
Used in Chemical Synthesis:
4-PYRIDINECARBOXALDEHYDE N-OXIDE is used as a reagent in the preparation of pyridine N-oxides, a class of compounds with various applications in the chemical and pharmaceutical industries. Its unique structure allows for the synthesis of a range of pyridine N-oxide derivatives with potential uses in different fields.

InChI:InChI=1/C6H5NO2/c8-5-6-1-3-7(9)4-2-6/h1-5H

Upstream product

• 132643-64-2 pyridine-4-aldehyde diacetate 
• 76037-07-5 pyridin-4-ylmethanediol N-oxide 
• 872-85-5 pyridine-4-carbaldehyde 
• 1003-67-4 4-methylpyridine-1-oxide 
• 66893-81-0 N-(4-pyridylmethylene)-t-butylamine N,N'-dioxide 

Downstream Products

• 99310-65-3 hydroxy-(1-oxy-[4]pyridyl)-acetonitrile 
• 66893-81-0 N-(4-pyridylmethylene)-t-butylamine N,N'-dioxide 
• 92577-25-8 4-pyridinecarboxaldehyde N-oxide phenylhydrazone 
• 66893-81-0 2-methyl-N-(4-pyridinylmethylene)-2-propanamine N,N'-dioxide 
• 1029017-11-5 1-benzyl-3-(4-(N-oxy-pyridinylmethylidenyl))indolin-2-one 
• 919834-61-0 4-[4-(4-fluorophenylamino)pyrimidin-2-ylamino]-N-[1-(1-N-oxidepyridin-4-ylmethyl)piperidin-4-yl]-N-methylbenzenesulfonamide 
• 1036017-18-1 5-((1-oxido-4-pyridinyl)methylene)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone 
• 872-85-5 pyridine-4-carbaldehyde 
• 16552-49-1 4-methoxy-N-(pyridin-4-ylmethyl)benzenamine 
• 129985-68-8 N-(4-methoxyphenyl)-1-(pyridin-4-yl)methanimine 

Relevant articles and documents

Formation of radicals during heating lysine and glucose in solution with an intermediate water activity

Heating glucose with lysine under alkaline conditions (pH 7.0-10.0) was found to take place with consumption of oxygen together with formation of brown-colored compounds. Highly reactive intermediary radicals were detected when lysine and glucose were heated at intermediate water activity at pH 7.0 and 8.0. The detection was based on initial trapping of highly reactive radicals by ethanol followed by spin trapping of 1-hydroxyethylradicals with α-(4-pyridyl N-oxide)-N-tert-butylnitrone (POBN) and Electron Spin Resonance (ESR) spectroscopy. The generation of reactive intermediary radicals from the Maillard reactions was favored by enhancing alkaline conditions (pH 8.0) and stimulated by presence of the transition metal ion Fe2+. The stability of the nitrone spin traps, N-tert-butyl-α-phenylnitrone and POBN was examined in buffered aqueous solutions within the pH range 1-12, and found to be less temperature dependent at acidic pH compared to alkaline conditions. A low rate (kobs) of hydrolysis of POBN was found at the used experimental conditions of 70°C and pH 7.0 and 8.0, which made this spin trap method suitable for the detection of radicals in the Maillard reaction system.

Aminooxyamide tricyclic inhibitors of farnesyl-protein transferase

Novel aminooxyamide tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

Hydration Constants of Pyridinecarboxaldehyde N-Oxides

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