72170-90-2

Basic information

• Product Name: (2S)-(-)-<(1E)-butylidenamino>-2-(methoxymethyl)pyrrolidine
• Synonyms: (2S)-(-)-<(1E)-butylidenamino>-2-(methoxymethyl)pyrrolidine
• CAS NO: 72170-90-2
• Molecular Weight: 184.282
• Mol File: 72170-90-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-(-)-<(1E)-butylidenamino>-2-(methoxymethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-(-)-<(1E)-butylidenamino>-2-(methoxymethyl)pyrrolidine(72170-90-2)
• EPA Substance Registry System: (2S)-(-)-<(1E)-butylidenamino>-2-(methoxymethyl)pyrrolidine(72170-90-2)

Safety Data

• Hazardous Substances Data: 72170-90-2(Hazardous Substances Data)

Upstream product

• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 123-72-8 butyraldehyde 

Downstream Products

• 825601-07-8 (2R,2S)-(-)-[2-(benzyloxymethyl)butylidene][2-(methoxymethyl)pyrrolidin-1-yl]amine 
• 825601-18-1 (1R,1'R,2S)-(-)-{1-[(1'-benzyloxymethyl)propyl]pentyl}[2-(methoxymethyl)pyrrolidin-1-yl]amine 
• 943987-65-3 [(2S,3S)-5-benzyloxy-3-(tert-butyldimethylsilanyloxy)-2-ethylpent-(E)-ylidene][(R)-2-methoxymethylpyrrolidin-1-yl]amine 

Relevant articles and documents

Asymmetric synthesis of 6-alkyl- And 6-arylpiperidin-2-ones. Enantioselective synthesis of (S)-(+)-coniine

A variety of diolefinic hydrazides (1) have been assembled in a highly diastereoselective manner by addition of allyllithium to chiral SAMP hydrazones followed by N-acylation with acryloyl chloride. Substrates 1 undergo ring-closing metathesis to give the cyclic enehydrazides (5) which can be easily converted into virtually enantlopure 6-alkyl- or 6-arylpiperidin-2-ones (7). The versatility of this hydrazone addition-RCM protocol has been further exemplified by the conversion of the unsaturated heterocycle 5b into the piperidine alkaloid (S)-(+)-coniine.