72177-82-3

Basic information

• Product Name: 2-AMino-4-Methylpentanenitrile Hydrochloride
• Synonyms: 2-AMino-4-Methylpentanenitrile Hydrochloride
• CAS NO: 72177-82-3
• Molecular Formula: C₆H₁₂N₂*ClH
• Molecular Weight: 148.63382
• Mol File: 72177-82-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMino-4-Methylpentanenitrile Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-4-Methylpentanenitrile Hydrochloride(72177-82-3)
• EPA Substance Registry System: 2-AMino-4-Methylpentanenitrile Hydrochloride(72177-82-3)

Safety Data

• Hazardous Substances Data: 72177-82-3(Hazardous Substances Data)

Usage

Use

Intermediate in pharmaceutical and agrochemical synthesis

Application

Building block for organic chemicals and pharmaceuticals, including anticancer agents and antiviral drugs

Physical Properties

Appearance: Colorless to off-white crystalline powder
Solubility: Soluble in water and organic solvents

Safety

Handle with care and follow safety precautions when working with it

Upstream product

• 81758-24-9 4-methyl-2-((trimethylsilyl)oxy)pentanenitrile 
• 151-50-8 potassium cyanide 
• 590-86-3 isovaleraldehyde 

Downstream Products

• 67337-73-9 5-isobutyl-imidazolidine-2,4-dione 
• 93019-88-6 2-(1-benzoylamino-3-methyl-butyl)-thiazole-4-carboxylic acid 
• 94931-13-2 2-(1-benzoylamino-3-methyl-butyl)-thiazole-4-carboxylic acid methyl ester 
• 95591-92-7 N-benzoyl-thioleucine amide 
• 65451-12-9 (RS)-leucinonitrile 
• 6377-03-3 N-(N-Acetyl-DL-leucyl)-aminoacetonitril 

Relevant articles and documents

Preparation of α-aminothioamides from aldehydes

The conversion of aldehydes into α-aminonitriles and thence into imidazolidin-4-thiones has been studied.Hydrolysis of the appropriate imidazolidin-4-thiones gave thioamides of nine naturally occuring α-amino acids.The possible pre-biotic significance of these compounds is discussed.

Heterocycles as Masked Diamide/Dipeptide Equivalents. Formation and Reactions of Substituted 5-(Acylamino)oxazoles as Intermediates en route to the Cyclopeptide Alkaloids

A variety of novel 2,4-dialkyl-5-(acylamino)oxazoles have been prepared by using either amide nitriles or diamides/dipeptides as starting materials.Ring closure calls for the use of trifluoroacetic acid/trifluoroacetic acid anhydride or an acid halide in