72198-15-3

Basic information

• Product Name: 3-chloro-4-hydroxymandelic acid
• Synonyms: 3-Chloro-4-hydroxymandelic acid; (3-chloro-4-hydroxyphenyl)(hydroxy)acetic acid
• CAS NO: 72198-15-3
• Molecular Formula: C₈H₇ClO₄
• Molecular Weight: 202.5918
• EINECS: 276-453-5
• Mol File: 72198-15-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 396.7°C at 760 mmHg
• Flash Point: 193.7°C
• Density: 1.614g/cm³
• Vapor Pressure: 5.26E-07mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: 3-chloro-4-hydroxymandelic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-hydroxymandelic acid(72198-15-3)
• EPA Substance Registry System: 3-chloro-4-hydroxymandelic acid(72198-15-3)

Safety Data

• Hazardous Substances Data: 72198-15-3(Hazardous Substances Data)

Upstream product

• 95-57-8 2-monochlorophenol 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 
• 156-38-7 4-hydroxyphenylacetate 
• 1148126-52-6 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethyl 2-(3-chloro-4-hydroxyphenyl)-2-hydroxyacetate 

Relevant articles and documents

Synthesis of mandelic acid derived phthalimides as a new class of antiinflammatory and antimicrobial agents

In the present study, a new series of 2-(1,3-dioxo-2,3-dihydro-1H-2- isoindolyl) ethyl 2-hydroxy-2-(substituted phenyl) acetates 6a-e have been synthesized from the combination of N-(2-hydroxy ethyl) phthalimide 5 and substituted mandelic acids 2a-e which resulted in both anti-inflammatory and antimicrobial activity. These compounds have been characterized by IR, 1H NMR, mass spectral and elemental analysis. Among the compounds tested for anti-inflammatory activity, compound 6b and 6c showed significant activity and compound 6d showed potent antibacterial and antifungal activity. The anti-inflammatory activity has been determined by carrageenan induced acute paw oedema in rats. The results are discussed in the text. The in vitro antibacterial and antifungal activity of the compounds have been evaluated by paper disc diffusion method. The minimum inhibitory concentrations (MIC) of the compounds have also been determined by agar streak dilution method.