722-92-9

Basic information

• Product Name: 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE
• Synonyms: 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE;4-AMINO-ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)BENZYL ALCOHOL;2-(4-AMINOPHENYL)HEXAFLUORO-2-PROPANOL;2-(4-AMINOPHENYL)-1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL;4-amino-à-à-bis(trifluoromethyl)benzyl alcohol;4-(Hexafluoro-2-hydroxyisopropyl)aniline 97%;4-(Hexafluoro-2-hydroxyisopropyl)aniline97%;2-(4-AMINO-PHENYL)-1,1,1,3,3,3-HEXAFLUORO-PROPAN-2-OL
• CAS NO: 722-92-9
• Molecular Formula: C₉H₇F₆NO
• Molecular Weight: 259.15
• Mol File: 722-92-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 147-152 °C
• Boiling Point: 292.9 °C at 760 mmHg
• Flash Point: 130.9 °C
• Appearance: Light brown/Crystalline Powder
• Density: 1.505 g/cm³
• Vapor Pressure: 0.000814mmHg at 25°C
• Refractive Index: 1.454
• Storage Temp.: Keep Cold under Argon
• PKA: 9.86±0.15(Predicted)
• BRN: 1473737
• CAS DataBase Reference: 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE(722-92-9)
• EPA Substance Registry System: 4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE(722-92-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• RIDADR: 2811
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 722-92-9(Hazardous Substances Data)

Usage

Chemical Properties

Light brown crystalline powder

InChI:InChI=1/C9H7F6NO/c10-8(11,12)7(17,9(13,14)15)5-1-3-6(16)4-2-5/h1-4,17H,16H2

Upstream product

• 62-53-3 aniline 
• 684-16-2 Hexafluoroacetone 
• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 

Downstream Products

• 137677-94-2 bis<2-(4-aminophenyl)hexafluoro-propyl> hexafluoroglutarate 
• 132428-02-5 1-(4-Fluorophenyl)-3-([N-[4-(2,2,2-trifluoro-1-hydroxy)-1-(trifluoromethyl)ethyl]phenyl]amino)-1-propanone 
• 137677-86-2 (3-Fluoro-4-nitro-phenyl)-carbamic acid 1-(4-amino-phenyl)-2,2,2-trifluoro-1-trifluoromethyl-ethyl ester 
• 2396-17-0 4-perfluoroisopropylaniline 
• 2402-66-6 p-Nitro-α,α-bis-(trifluormethyl)-benzylalkohol 
• 76856-51-4 N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzenesulfonamide 
• 876143-24-7 N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-pyridine-2-carboxamidine 
• 876143-23-6 N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-isonicotinamidine 
• 876143-22-5 N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-isobutyramidine 
• 444622-44-0 2-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-butyramidine 
• 892121-52-7 4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-phenylamine 
• 1992-24-1 N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-acetamide 
• 70430-20-5 2,2,2-trifluoro-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-acetamide 
• 872690-44-3 2-[4-(benzyl-ethyl-amino)-phenyl]-1,1,1,3,3,3-hexafluoro-propan-2-ol 

Relevant articles and documents

Cobalt-Catalyzed Selective Functionalization of Aniline Derivatives with Hexafluoroisopropanol

A cobalt-catalyzed site-selective functionalization of aniline derivatives with hexafluoroisopropanol, which enables the synthesis of a wide array of fluoroalkylated anilines, a class of highly valuable building blocks for further preparation of fluorinated functional products, is reported. The developed transformation proceeds with operational simplicity, use of earth-abundant metal catalyst, broad substrate scope, good functional group tolerance, and mild reaction conditions.

Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils

Polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils, such as 1,2-dihydro-8-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-6-methyl-4H-pyrrolo-[3,2,1-ij]quinolin-7-one, useful as antihypertensive agents.