72233-47-7Relevant articles and documents
Enantioselective palladium(0)-catalyzed nazarov-type cyclization
Kitamura, Kei,Shimada, Naoyuki,Stewart, Craig,Atesin, Abdurrahman C.,Atein, Tülay A.,Tius, Marcus A.
supporting information, p. 6288 - 6291 (2015/05/20)
A Pd0-catalyzed asymmetric Nazarov-type cyclization is described. The optimized ligand for the reaction incorporates a weakly coordinating pyridine ring into a TADDOL-derived phosphoramidite (TADDOL=α,α,α,α-tetraaryl-1,3-dioxolane-4,5-dimethanol). The reaction leads to the formation of cyclopentenones as single diastereoisomers that incorporate two contiguous asymmetric centers, one tertiary and one an all-carbon-atom quaternary stereocenter, in high yield and optical purity. It is noteworthy that the reaction does not require that substrates should be activated by aryl substituents.
Dihydroquinolines as novel n-NOS inhibitors
Jaroch, Stefan,Hoelscher, Peter,Rehwinkel, Hartmut,Suelzle, Detlev,Burton, Gerardine,Hillmann, Margrit,McDonald, Fiona M.
, p. 2561 - 2564 (2007/10/03)
Dihydroquinolines have been synthesized and have been shown to be potent n-NOS inhibitors. Selectivity versus e-NOS was increased to approximately 100-fold through appropriate substitution at the benzene ring.
