72235-51-9

Basic information

• Product Name: 2,3-Difluorobenzylamine
• Synonyms: 2,3-DIFLUOROBENZYLAMINE;RARECHEM AL BW 0288;Difluorobenzylamine1;2,3-Difluorobenzylamine 98%;2,3-Difluorobenzylamine98%;2,3-Difluorobenzyamine;(2,3-Difluorophenyl)methanamine;2,3-Difluorobenzylam
• CAS NO: 72235-51-9
• Molecular Formula: C₇H₇F₂N
• Molecular Weight: 143.13
• Product Categories: Amine;Amines;C7;Nitrogen Compounds;Fluorine series
• Mol File: 72235-51-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 65 °C4 mm Hg(lit.)
• Flash Point: 171 °F
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.223 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.981mmHg at 25°C
• Refractive Index: n20/D 1.495(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.38±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2,3-Difluorobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluorobenzylamine(72235-51-9)
• EPA Substance Registry System: 2,3-Difluorobenzylamine(72235-51-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 72235-51-9(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

InChI:InChI=1/C7H7F2N/c8-6-3-1-2-5(4-10)7(6)9/h1-3H,4,10H2/p+1

Upstream product

• 21524-39-0 2,3-difluorobenzonitrile 
• 923845-93-6 2-(3-chloro-2-fluorobenzyl)-4,5-dihydroxyisoindoline-1,3-dione 
• 113211-94-2 2,3-difluorobenzyl bromide 

Downstream Products

• 936219-35-1 3-(2,3-dichlorophenyl)-4-(2,3-difluorobenzyl)-4H-1,2,4-triazole 
• 957112-79-7 C₃₃H₄₀F₃N₃O₆ 
• 480458-49-9 C₂₇H₂₃F₃N₆ 
• 1028337-32-7 4-chloro-6-(2,3-difluoro-benzylamino)-2H-phthalazin-1-one 
• 1229011-33-9 (2Z,4Z)-N-(2,3-difluorobenzyl)-8,9-difluoro-5-(2-hydroxyphenyl)-1H-benzo[C]azepine-4-carboxamide 
• 1111266-29-5 C₂₈H₂₉F₂N₉OS 
• 1394930-52-9 2-amino-5-bromo-N-[(2,3-difluorophenyl)methyl]pyridine-3-carboxamide 

Relevant articles and documents

MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of preparing such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor.

The pattern of fluorine substitution affects binding affinity in a small library of fluoroaromatic inhibitors for carbonic anhydrase

(equation presented) A library of fluoroaromatic inhibitors of carbonic anhydrase has been found to bind in a manner dependent on both hydrophobicity and the pattern of substitution of the fluoroaromatic ring. All of the compounds in the library bind to the protein with Kd 3 nM. We have inferred two distinct binding modes from our data, which suggest two types of interactions that should be considered when designing fluorinated drugs.