722459-38-3

Basic information

• Product Name: 2-naphthyl(4-phenyl-1H-pyrrol-3-yl)methanone
• Synonyms: 2-naphthyl(4-phenyl-1H-pyrrol-3-yl)methanone
• CAS NO: 722459-38-3
• Molecular Formula: C₂₁H₁₅NO
• Molecular Weight: 297.3499
• Mol File: 722459-38-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-naphthyl(4-phenyl-1H-pyrrol-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-naphthyl(4-phenyl-1H-pyrrol-3-yl)methanone(722459-38-3)
• EPA Substance Registry System: 2-naphthyl(4-phenyl-1H-pyrrol-3-yl)methanone(722459-38-3)

Safety Data

• Hazardous Substances Data: 722459-38-3(Hazardous Substances Data)

Upstream product

• 4782-69-8 (E)-1-(naphthalen-2-yl)-3-phenylprop-2-en-1-one 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 100-52-7 benzaldehyde 
• 4782-69-8 1-(naphthalen-2-yl)-3-phenylprop-2-en-1-one 

Downstream Products

• 150359-02-7 1-[Naphthalen-2-yl-(4-phenyl-1H-pyrrol-3-yl)-methyl]-1H-imidazole 

Relevant articles and documents

Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones

A metal-free approach for the synthesis of 2-acylpyrroles is reported in this paper. Synthesis of the target molecule started from chalcones and was carried out in two steps. Initial step involved the conversion of chalcones to corresponding 4-substituted-3-acylpyrroles by reaction with TosMIC. In the subsequent step, target molecules were obtained in modest to good yields by polyphosphoric acid-mediated acyl rearrangement of 3-acylpyrroles to their 2-acyl congeners. The crucial final step was amenable to diverse substitutions on pyrrole ring. Preliminary experiment for the determination of mechanism indicated the involvement of acylium ion.