722539-56-2

Basic information

• Product Name: ethyl 3-(2-hydroxy-3-hydroxymethyl-phenyl)propionate
• Synonyms: ethyl 3-(2-hydroxy-3-hydroxymethyl-phenyl)propionate
• CAS NO: 722539-56-2
• Molecular Weight: 224.257
• Mol File: 722539-56-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-(2-hydroxy-3-hydroxymethyl-phenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(2-hydroxy-3-hydroxymethyl-phenyl)propionate(722539-56-2)
• EPA Substance Registry System: ethyl 3-(2-hydroxy-3-hydroxymethyl-phenyl)propionate(722539-56-2)

Safety Data

• Hazardous Substances Data: 722539-56-2(Hazardous Substances Data)

Upstream product

• 119-84-6 C₆H₄(CH₂CH₂C(O)O) 
• 50-00-0 formaldehyd 
• 20921-04-4 ethyl 3-(2-hydroxyphenyl)propanoate 

Relevant articles and documents

Second Generation of cycloSal-Pronucleotides with Esterase-Cleavable Sites: The "Lock-In"-Concept

A conceptual extension of the cycloSal-pronucleotide approach is presented. The characteristic feature of the new cycloSal-derivatives of the anti-HIV active nucleoside analogue d4T 1 is the incorporation of an enzymatically cleavable carboxylic ester moiety with the intention to trap the triesters inside cells ("lock-in"-concept). CycloSal-triesters bearing different ester groups in the 3-or 5-position of the cycloSal-moiety are described. Surprisingly, only acetyl-and levulinyl esters are cleaved readily in CEM cell extracts while alkyl esters were found to be stable. Nevertheless, in in-vitro anti-HIV assays most of the compounds achieve the thymidine-kinase bypass, thus proving that they act at least as nucleotide delivery systems.