7227-49-8

Basic information

• Product Name: N-{1-[(2,2-dimethoxyethyl)carbamoyl]-2-phenylethenyl}-Nalpha-(trifluoroacetyl)phenylalaninamide
• CAS NO: 7227-49-8
• Molecular Formula: C₂₄H₂₆F₃N₃O₅
• Molecular Weight: 493.4755
• Mol File: 7227-49-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 731.8°C at 760 mmHg
• Flash Point: 396.4°C
• Density: 1.274g/cm³
• Vapor Pressure: 2.84E-21mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: N-{1-[(2,2-dimethoxyethyl)carbamoyl]-2-phenylethenyl}-Nalpha-(trifluoroacetyl)phenylalaninamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{1-[(2,2-dimethoxyethyl)carbamoyl]-2-phenylethenyl}-Nalpha-(trifluoroacetyl)phenylalaninamide(7227-49-8)
• EPA Substance Registry System: N-{1-[(2,2-dimethoxyethyl)carbamoyl]-2-phenylethenyl}-Nalpha-(trifluoroacetyl)phenylalaninamide(7227-49-8)

Safety Data

• Hazardous Substances Data: 7227-49-8(Hazardous Substances Data)

Upstream product

• 79-19-6 thiosemicarbazide 

Relevant articles and documents

Copper complexes with dissymmetrically substituted bis(thiosemicarbazone) ligands as a basis for PET radiopharmaceuticals: Control of redox potential and lipophilicity

Copper(ii) bis(thiosemicarbazone) derivatives have been used extensively in positron emission tomography (PET) to image hypoxia and blood flow and to radiolabel cells for cell tracking. These applications depend on control of redox potentials and lipophilicity of the bis(thiosemicarbazone) complexes, which can be adjusted by altering peripheral ligand substituents. This paper reports the synthesis of a library of new dissymmetrically substituted bis(thiosemicarbazone) ligands by controlling the condensation reactions between dicarbonyl compounds and 4-substituted-3-thiosemicarbazides or using acetal protection. Copper complexes of the new ligands have been prepared by reaction with copper acetate or via transmetallation of the corresponding zinc complexes, which are convenient precursors for the rapid synthesis of radio-copper complexes. Well-defined structure-activity relationships linking ligand alkylation patterns with redox potential and lipophilicity of the complexes are reported.