723-69-3

Basic information

• Product Name: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID
• Synonyms: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID;(4-Fluoro-phenyl)-phenyl-acetic acid
• CAS NO: 723-69-3
• Molecular Formula: C₁₄H₁₁FO₂
• Molecular Weight: 230.23
• Mol File: 723-69-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 104-106 °C
• Boiling Point: 346.2 °C at 760 mmHg
• Flash Point: 163.2 °C
• Appearance: /
• Density: 1.244 g/cm³
• Vapor Pressure: 2.22E-05mmHg at 25°C
• Refractive Index: 1.582
• PKA: 4.73±0.10(Predicted)
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID(723-69-3)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)-2-PHENYLACETIC ACID(723-69-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 723-69-3(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)-2-phenylacetic acid is a compound with the chemical formula C16H13FO2. It is a white to off-white crystalline powder that is used as a building block in the synthesis of pharmaceuticals and other organic compounds. This chemical is often utilized as an intermediate in the production of nonsteroidal anti-inflammatory drugs (NSAIDs) such as flurbiprofen. It is also known for its analgesic and anti-inflammatory properties, and is commonly used in the treatment of pain, inflammation, and fever. However, it is important to handle this chemical with caution and follow proper safety protocols, as it can be harmful if not used properly.

InChI:InChI=1/C14H11FO2/c15-12-8-6-11(7-9-12)13(14(16)17)10-4-2-1-3-5-10/h1-9,13H,(H,16,17)

Upstream product

• 103-82-2 phenylacetic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Cross-electrophile couplings between two electrophiles are powerful and economic methods to generate C-C bonds in the presence of stoichiometric external reductants. Herein, we report a novel strategy to realize the first external-reductant-free cross-electrophile coupling via visible-light photoredox catalysis. A variety of tetraalkyl ammonium salts, bearing primary, secondary, and tertiary C-N bonds, undergo selective couplings with aldehydes/ketone and CO2. Notably, the in situ generated byproduct, trimethylamine, is efficiently utilized as the electron donor. Moreover, this protocol exhibits mild reaction conditions, low catalyst loading, broad substrate scope, good functional group tolerance, and facile scalability. Mechanistic studies indicate that benzyl radicals and anions might be generated as the key intermediates via photocatalysis, providing a new direction for cross-electrophile couplings.