7230-41-3

Basic information

• Product Name: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid
• Synonyms: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid
• CAS NO: 7230-41-3
• Molecular Formula: C₁₃H₁₂FNO₂S
• Molecular Weight: 237.212
• Mol File: 7230-41-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 500.9°C at 760 mmHg
• Flash Point: 256.7°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 7.5E-11mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid(7230-41-3)
• EPA Substance Registry System: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid(7230-41-3)

Safety Data

• Hazardous Substances Data: 7230-41-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11N3O4/c14-10(15)8-2-1-5-12(8)9-4-3-7(6-11-9)13(16)17/h3-4,6,8H,1-2,5H2,(H,14,15)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 1993-03-9 o-fluorophenylboronic acid 
• 127-65-1 chloroamine-T 
• 824-79-3 sodium 4-methylbenzenesulfinate 

Downstream Products

• 253602-53-8 N-(2-Fluorophenyl)-N-(2-hydroxy-3-phenoxypropyl)toluene-p-sulfonamide 
• 253602-54-9 (2R)-N-(2-Fluorophenyl)-N-(2-hydroxy-3-benzyloxypropyl)toluene-p-sulfonamide 
• 348-54-9 2-Fluoroaniline 
• 253602-58-3 2-benzyloxymethyl-3,4-dihydro-2H-benzo[1,4]oxazine 
• 253602-55-0 N-Tosyl-2-phenoxymethyl-1,4-benzoxazine 
• 253602-56-1 2-benzyloxymethyl-4-(toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1386995-95-4 N-(2-fluorophenyl)-2-phenyl-N-tosylbutanamide 

Relevant articles and documents

Metal-free one-pot synthesis of N-arylsulfonamides from nitroarenes and sodium sulfinates in an aqueous medium

A metal-free one-pot two-step synthesis of sulfonamides from readily available nitroarenes and sodium arylsulfinates in a mixture of methanol and water has been developed. In this procedure, the aryl amines were produced in situ by the reduction of nitroarenes mediated by diboronic acid, and then coupled with sodium arylsulfinates in the presence of iodine. A series of N-arylsulfonamides with various functional groups were obtained in moderate to good yields under the optimal reaction conditions. In addition, this one-pot process is applicable for gram-scale synthesis.

Differentiation of isomeric haloanilines by tosylation in combination with electrospray ionization mass spectrometry

Differentiation of the isomeric haloanilines still remains a challenging and?necessary?analytic task due to their identical retention time in chromatography and similar mass spectra. In this work, p-tosylation of haloanilines by reaction of haloanilines with p-toluenesulfonyl chloride resulted in the corresponding N-tosyl haloanilines. Fragmentation of protonated N-tosyl haloanilines in electrospray ionization tandem mass spectrometry (ESI-MS/MS) mainly resulted in tosyl cation, haloaniline radical cation, and halohydroxyaniline radical cation. The MS/MS of the three group isomeric derivatives showed significant difference in abundance distribution of these product ions, respectively. Theoretical calculations showed that the stability of the ion-neutral complex (INC) is a key factor influencing the relative intensity of the product ions. The three group isomeric derivatives were also separated by high performance liquid chromatograph (HPLC) at conventional conditions. p-Tosylation combined tandem MS (or HPLC) technique were carried out to realize the differentiation of isomeric haloanilines.

Synthesis of N -Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature

A copper-catalyzed Chan-Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N -arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups. In this process, it is believed that chloramine-T serves as an electrophile.