723284-38-6

Basic information

• Product Name: 2-[(dibenzo[b,d]furan-2-yl)oxy]-1-(4-fluorophenyl)ethan-1-one
• Synonyms: 2-[(dibenzo[b,d]furan-2-yl)oxy]-1-(4-fluorophenyl)ethan-1-one
• CAS NO: 723284-38-6
• Molecular Weight: 320.32
• Mol File: 723284-38-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(dibenzo[b,d]furan-2-yl)oxy]-1-(4-fluorophenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(dibenzo[b,d]furan-2-yl)oxy]-1-(4-fluorophenyl)ethan-1-one(723284-38-6)
• EPA Substance Registry System: 2-[(dibenzo[b,d]furan-2-yl)oxy]-1-(4-fluorophenyl)ethan-1-one(723284-38-6)

Safety Data

• Hazardous Substances Data: 723284-38-6(Hazardous Substances Data)

Upstream product

• 86-77-1 2-hydroxydibenzofuran 
• 403-29-2 2-bromo-4'-fluoroacetophenone 

Relevant articles and documents

Synthesis and Cytotoxic and Antiplatelet Activities of Dibenzofuran- and Carbazole-Substituted Oximes

The dibenzofuran- and carbazole-substituted oximes or methyloximes 5-10 were prepared and evaluated for their cytotoxic and antiplatelet activities. These compounds were synthesized via alkylation of dibenzofuran-2-ol or 9H-carbazol-2-ol with α-halocarbonyl reagents, followed by reaction with NH2OH or NH2OMe (Scheme). A preliminary anticancer assay indicated that the oxime-type dibenzofuran derivatives 5 and 7a-d are active, while the corresponding oxime ethers 9h and 9c are inactive at the same concentration. Therefore, a H-bond-donating group seems to be crucial for cytotoxicity. Among the compounds tested, 2-[(dibenzo[b,d]-furan-2-yl)oxy]-1-(4-methoxyphenyl)ethan-1-one O-methyloxime (9c) exhibited potent inhibitory activity against platelet aggregation induced by arachidonic acid, with an IC50 value of 14.87 μM, without being cytotoxic at a concentration of 100 μM.