72331-27-2

Basic information

• Product Name: 4-oxycyano-benzoic acid methyl ester
• Synonyms: 4-oxycyano-benzoic acid methyl ester
• CAS NO: 72331-27-2
• Molecular Weight: 177.159
• Mol File: 72331-27-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-oxycyano-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxycyano-benzoic acid methyl ester(72331-27-2)
• EPA Substance Registry System: 4-oxycyano-benzoic acid methyl ester(72331-27-2)

Safety Data

• Hazardous Substances Data: 72331-27-2(Hazardous Substances Data)

Upstream product

• 168699-41-0 methyl 4-[(1E)-(hydroxyimino)methyl]benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 53148-13-3 4-(hydroxyiminomethyl)benzoic acid methyl ester 

Downstream Products

• 352550-81-3 4-[5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalen-2-yl)isoxazol-3-yl]benzoic acid methyl ester 
• 352550-79-9 4-[5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalen-2-yl)-4,5-dihydroisoxazol-3-yl]benzoic acid methyl ester 

Relevant articles and documents

Novel access to 2-substituted quinolin-4-ones by nickel boride-mediated reductive ring transformation of 5-(2-nitrophenyl)isoxazoles

Reductive ring transformation of 3-substituted 5-(2-nitrophenyl)isoxazoles, readily accessible via 1,3-dipolar cycloaddition of 2-ethinylnitrobenzene with nitrile oxides, opens a novel access to 2-substituted quinolin-4-ones. Nickel boride, generated in situ from nickel chloride and sodium borohydride, allows, via simultaneous reduction of the nitro group and reductive cleavage of the isoxazole ring, the one-step conversion into the target quinolin-4-ones. This protocol tolerates various functional groups, except olefins, and thus is complementary to the reductive ring transformation with iron/acetic acid, which predominantly tolerates olefins.