72336-16-4

Basic information

• Product Name: N-benzyl-N~2~,N~2~-diethylglycinamide
• Synonyms: acetamide, 2-(diethylamino)-N-(phenylmethyl)-; N-Benzyl-N~2~,N~2~-diethylglycinamide
• CAS NO: 72336-16-4
• Molecular Formula: C₁₃H₂₀N₂O
• Molecular Weight: 220.3107
• Mol File: 72336-16-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 382.5°C at 760 mmHg
• Flash Point: 185.1°C
• Density: 1.01g/cm³
• Vapor Pressure: 4.7E-06mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: N-benzyl-N~2~,N~2~-diethylglycinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N~2~,N~2~-diethylglycinamide(72336-16-4)
• EPA Substance Registry System: N-benzyl-N~2~,N~2~-diethylglycinamide(72336-16-4)

Safety Data

• Hazardous Substances Data: 72336-16-4(Hazardous Substances Data)

Upstream product

• 2564-06-9 N-benzyl-2-chloroacetamide 
• 109-89-7 diethylamine 
• 100-46-9 benzylamine 
• 100-37-8 2-(Diethylamino)ethanol 
• 30280-35-4 N,N-diethylglycine methyl ester 

Downstream Products

• 15855-37-5 N,N-diethyl-N'-benzylethylenediamine 

Relevant articles and documents

Carboxyesterase polypeptides for amide coupling

The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.

Synthesis, structure and anticancer activity of copper(II) complexes of N-benzyl-2-(diethylamino)acetamide and 2-(diethylamino)-N-phenylethylacetamide

The ligands N-benzyl-2-(diethylamino)acetamide, (HL1) and 2-(diethylamino)-N-phenylethylacetamide (HL2), have been used to synthesize copper(II) complexes, [Cu(HL1)2](ClO 4)2 (1) and [Cu(HL2)2](ClO 4)2 (2), respectively. Both complexes are well characterized by various spectral and physical methods. The crystal structure of complex (1) reveals that two bidentate ligands coordinate the Cu(II) ion via Oamide and Namine atoms in the basal plane whereas one of the ClO4- ions occupies the apical position maintaining a square-pyramidal geometry. Screening results for anti-proliferative studies against the U87 and HeLa cancerous cells indicate promising activity. The complexes enhanced growth inhibition and cell death in a concentration and time dependent manner for both U87 and HeLa cell lines. Of the two compounds, complex (2) exhibits better activity against both HeLa and U87 cells. Further, both complexes are specifically potent against U87 after 72 h of treatment. Micronucleus and apoptosis frequencies are 3 - 4 times higher in treated cells when compared with untreated control. Despite potent in vitro activity, both complexes exhibit diminished cytotoxicity against the normal human HEK cells at all effective concentrations.