72351-28-1

Basic information

• Product Name: Phosphinic acid, bis(1H-1,2,4-triazol-1-yl)-, 2-chlorophenyl ester
• CAS NO: 72351-28-1
• Molecular Formula: C10H8ClN6O2P
• Molecular Weight: 310.639
• Mol File: 72351-28-1.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Phosphinic acid, bis(1H-1,2,4-triazol-1-yl)-, 2-chlorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphinic acid, bis(1H-1,2,4-triazol-1-yl)-, 2-chlorophenyl ester(72351-28-1)
• EPA Substance Registry System: Phosphinic acid, bis(1H-1,2,4-triazol-1-yl)-, 2-chlorophenyl ester(72351-28-1)

Safety Data

• Hazardous Substances Data: 72351-28-1(Hazardous Substances Data)

Upstream product

• 288-88-0 1,2,4-Triazole 
• 15074-54-1 2-chlorophenyl dichlorophosphate 

Downstream Products

• 81705-89-7 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine 2'-(2-chlorophenyl) phosphomonotriazolide 
• 121768-15-8 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N⁽⁶⁾-benzoyladenosine-2' (2-chlorophenyl) Phosphoro-(1,2,4-triazolidate) 
• 89947-92-2 Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine 
• 77451-40-2 N⁶-benzoyl-2'-O-(4-methoxytetrahydropyran-4-yl)-5'-O-adenosine 3'-<(o-chlorophenyl)triethylammonium phosphate> 
• 115590-40-4 Phosphoric acid (2R,3R,4S,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester; compound with triethyl-amine 
• 99272-63-6 4-[(2R,3R,4R,5R)-2-(3-Benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester; compound with triethyl-amine 
• 99272-65-8 4-[(2R,3R,4R,5R)-2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester; compound with triethyl-amine 
• 99272-67-0 triethylammonium salt of 2'-O-(3-methoxy-1,5-dicarbomethoxypentanyl)-5'-O-pixyl-3'-O-(o-chlorophenyl)-phosphate-6-N-benzoyladenosine 
• 99272-69-2 4-[(2R,3R,4R,5R)-2-[2-(4-tert-Butyl-benzoylamino)-6-oxo-1,6-dihydro-purin-9-yl]-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yloxy]-4-methoxy-heptanedioic acid dimethyl ester; compound with triethyl-amine 
• 115561-38-1 Phosphoric acid 2-chloro-phenyl ester (2R,3R,4S,5R)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-3-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester; compound with triethyl-amine 
• 126709-04-4 methyl 2,6-anhydro-2-C--3-deoxy-4,5:7,8-bis-O-(isopropylidene)-D-glycero-D-talo-octonate 
• 126709-05-5 bis-2-chlorophenylphosphate 
• 79913-54-5 5'-O-methoxytetrahydropyranylthymidine 3'-(o-chlorophenyl) phosphate 
• 181259-73-4 Benzoic acid (2R,3R,4R,5R)-5-(6-benzylamino-purin-9-yl)-4-{(2-chloro-phenoxy)-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 

Relevant articles and documents

REACTION BETWEEN NUCLEOSIDE BASE AND THE PHOSPHORYLATING AGENT DERIVED FROM 1-HYDROXYBENZOTRIAZOLE AND 2-CHLOROPHENYL PHOSPHORODICHLORIDATE

In the presence of 1-methylimidazole, 2-N-acyl guanine (as in 4a), thymine (as in 5a), and uracil (as in 5b) residues react readily with the phosphorylating agent derived from 2-chlorophenyl phosphorodichloridate (1a) and 1-hydroxybenzotriazole.

DINUCLEOTIDE COMPOUNDS FOR TREATING CANCERS AND MEDICAL USES THEREOF

The present disclosure provides the dinucleotide compounds which is useful for treating various cancers. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating cancer. The present disclosure also provides a method of treatment of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment.

Recognition and inhibition of HIV integrase by novel dinucleotides

HIV integrase is involved in the integration of viral DNA into chromosomal DNA, a biological process that occurs by a sequence involving HIV DNA splicing and subsequent integration steps. In the quest for small nucleotide systems with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered novel, nuclease-resistant dinucleotides with defined base sequences that are inhibitors of this key viral enzyme. Synthetic methodologies utilized for the syntheses of the novel dinucleotides include an excellent new phosphorylating agent.