7239-60-3Relevant articles and documents
Efficient Stereoselective Synthesis of a Key Chiral Aldehyde Intermediate in the Synthesis of Picolinamide Fungicides
Li, Fangzheng,Good, Steffen,Tulchinsky, Michael L.,Whiteker, Gregory T.
, p. 2253 - 2260 (2019/10/16)
A highly stereoselective and efficient synthesis of (4S,5S,6S)-6-(benzyloxy)-5-phenoxy-4-propoxyheptanal, a key intermediate for syntheses of picolinamide fungicides, is described in this report. The synthesis features a scalable allylpropyl ether preparation, an efficient synthesis of the C1-C3 anti,syn-(S,S,S) stereotriad via a highly diastereoselective allylboration, and Cu-catalyzed phenylation of a sterically hindered secondary alcohol with BiPh3(OAc)2 followed by highly regioselective hydroformylation with the formation of a linear aldehyde. Excellent overall route efficiency was achieved (six steps and 39% yield) starting from readily available and inexpensive (S)-ethyl lactate.
Facile one-pot synthesis of triphenylbismuth(V) bis(carboxylate) complexes
Kumar, Ish,Bhattacharya, Prateek,Whitmire, Kenton H.
, p. 2906 - 2909 (2014/06/24)
Triphenylbismuth(V) bis(carboxylates), Ph3Bi(O 2CR)2 (R = 5-Br-2-OH-C6H3 (1), 2-OH-C6H4 (2), 2,6-(OH)2-C6H 3 (3), 3-Me-2-NH2-C6H3 (4), Ph (5), Me (6)), were obtained from the reaction of triphenylbismuth with hydrogen peroxide and excess carboxylic acid in wet 2-propanol. The synthesis avoids the use of halogens as oxidants, and the products crystallize directly from the solution as pure compounds. They crystallize from solution without further need for purification. The structures of 1-5 were confirmed by single-crystal X-ray diffraction. Compounds 2 and 5 exhibit a polymorph different from that previously reported in the literature. While all of the Bi(V) compounds adopt a trans-axial trigonal-bipyramidal configuration with the carboxylates in axial positions, there is considerable variation in the coordination of the carboxylate that ranges from simple η1 to a mixture of mono- and bidentate chelating bonding modes.
3-SUBSTITUTED QUINOLINIUM AND 7H-INDOLO[2,3-c]QUINOLINIUM SALTS AS NEW ANTIINFECTIVES
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Page/Page column 12, (2012/07/13)
The present invention relates to quinolinium antiinfective agents in which the qunolinium nucleus is fused to an indole ring or the qunolinium nucleus is linked to a cyclic structure through an opened indole or a benzothiophene or benzofuran ring. The compound is further substituted with various substituent groups. The compounds are represented by formula (I), (II) and (III): Pharmaceutical compositions and methods of use are also included.
