72411-89-3

Basic information

• Product Name: 4-MethoxypyriMidine-5-carboxylic Acid
• Synonyms: 4-MethoxypyriMidine-5-carboxylic Acid;5-PyriMidinecarboxylic acid, 4-Methoxy-;4-methoxy-5-Pyrimidinecarboxylic acid
• CAS NO: 72411-89-3
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12344
• Mol File: 72411-89-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 200 °C(Solv: N,N-dimethylformamide (68-12-2))
• Boiling Point: 334.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.371±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.06±0.16(Predicted)
• CAS DataBase Reference: 4-MethoxypyriMidine-5-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MethoxypyriMidine-5-carboxylic Acid(72411-89-3)
• EPA Substance Registry System: 4-MethoxypyriMidine-5-carboxylic Acid(72411-89-3)

Safety Data

• Hazardous Substances Data: 72411-89-3(Hazardous Substances Data)

Usage

Description

4-Methoxypyrimidine-5-carboxylic Acid is an organic compound with the chemical formula C5H4N2O3. It is a derivative of pyrimidine, a heterocyclic aromatic organic compound consisting of a six-membered ring containing four nitrogen atoms. The presence of a methoxy group (-OCH3) and a carboxylic acid group (-COOH) at the 4th and 5th positions, respectively, gives this compound unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
4-Methoxypyrimidine-5-carboxylic Acid is used as a key intermediate in the synthesis of 3-nortropane derivatives, which are known for their anti-psychotic activity. These derivatives have the potential to be developed into new medications for the treatment of various psychiatric disorders, such as schizophrenia and bipolar disorder. The presence of the methoxy and carboxylic acid groups in 4-Methoxypyrimidine-5-carboxylic Acid allows for further chemical modifications and the development of more potent and selective anti-psychotic agents.
In the synthesis of 3-nortropane derivatives, 4-Methoxypyrimidine-5-carboxylic Acid serves as a building block, providing a foundation for the creation of more complex molecular structures with improved pharmacological properties. The carboxylic acid group can be used to form amide bonds with other molecules, while the methoxy group can influence the lipophilicity and stability of the final product, potentially enhancing its bioavailability and therapeutic efficacy.
Overall, 4-Methoxypyrimidine-5-carboxylic Acid is a versatile compound with significant potential in the development of novel anti-psychotic medications. Its unique chemical structure and reactivity make it an important component in the ongoing search for more effective treatments for psychiatric disorders.

Upstream product

• 84332-00-3 methyl 4-methoxypyrimidine-5-carboxylate 
• 41103-17-7 ethyl 4-chloropyrimidine-5-carboxylate 

Downstream Products

• 72412-44-3 4-Methoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride 
• 72412-47-6 4-Methoxy-pyrimidine-5-carboxylic acid (1-benzyl-piperidin-4-yl)-amide 
• 84923-00-2 4-Methoxy-pyrimidine-5-carboxylic acid ((1R,3S,5S)-8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide 

Relevant articles and documents

Studies on the neuroleptic benzamides. I. - Synthesis and antidopaminergic properties of new pyrimidine derivatives

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