72417-82-4

Basic information

• Product Name: 2-{[(4-chlorophenyl)(phenyl)methyl]amino}benzoic acid
• Synonyms: benzoic acid, 2-[[(4-chlorophenyl)phenylmethyl]amino]-
• CAS NO: 72417-82-4
• Molecular Formula: C₂₀H₁₆ClNO₂
• Molecular Weight: 337.7995
• Mol File: 72417-82-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 506.7°C at 760 mmHg
• Flash Point: 260.2°C
• Density: 1.309g/cm³
• Vapor Pressure: 4.34E-11mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 2-{[(4-chlorophenyl)(phenyl)methyl]amino}benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(4-chlorophenyl)(phenyl)methyl]amino}benzoic acid(72417-82-4)
• EPA Substance Registry System: 2-{[(4-chlorophenyl)(phenyl)methyl]amino}benzoic acid(72417-82-4)

Safety Data

• Hazardous Substances Data: 72417-82-4(Hazardous Substances Data)

Upstream product

• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 118-92-3 anthranilic acid 

Relevant articles and documents

A Radical Pathway for Direct Substitution of Benzyl Alcohols with Water-Soluble Copper Catalyst in Water

We have developed a novel strategy for the direct substitution of benzyl alcohols with anthranilic acids using water-soluble copper catalysts through a radical pathway in water, which offers efficient and environmentally friendly N-, S-, and C-benzylations under neutral conditions. Radical scavengers strongly inhibited the benzylation. Radical clock experiments using α-cyclopropylbenzyl alcohol were conducted to observe the rapid isomerization of the cyclopropylmethyl radical to the allylmethyl radical. Hammett plots could be fitted to a two-parameter Hammett relationship containing both radical and polar contributions [log (kX/kH)=-1.24 σ.-0.38 σ, R2=0.99]. The relative parameter ρ./ρ of 3.3 suggested that these reactions involved a strong radical character with minor polar influence at the transition state.

Synthesis, antibacterial and analgesic activities of benzhydryl derivatives of hydroxy- and amino-benzoic acids

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