72459-47-3

Basic information

• Product Name: 1-(3-BROMOBENZYL)-1H-IMIDAZOLE
• Synonyms: 1-(3-BROMOBENZYL)-1H-IMIDAZOLE;1-(3-Bromobenzyl)-1H-imidazole 97%
• CAS NO: 72459-47-3
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237.1
• Mol File: 72459-47-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 62 °C
• Boiling Point: 371.455°C at 760 mmHg
• Flash Point: 178.45°C
• Appearance: /
• Density: 1.441g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 1-(3-BROMOBENZYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-BROMOBENZYL)-1H-IMIDAZOLE(72459-47-3)
• EPA Substance Registry System: 1-(3-BROMOBENZYL)-1H-IMIDAZOLE(72459-47-3)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 72459-47-3(Hazardous Substances Data)

Usage

General Description

1-(3-Bromobenzyl)-1H-imidazole is a chemical compound containing an imidazole ring with a bromobenzyl group attached to it. It is commonly used in organic synthesis as a building block for creating various chemical compounds. The bromobenzyl group provides reactivity, making it suitable for forming new bonds with other molecules. 1-(3-BROMOBENZYL)-1H-IMIDAZOLE has potential applications in pharmaceuticals, agrochemicals, and materials science. It is important to handle this chemical with caution due to its potential hazards and risks, and proper safety measures should be followed when working with it.

InChI:InChI=1/C10H9BrN2/c11-10-3-1-2-9(6-10)7-13-5-4-12-8-13/h1-6,8H,7H2

Upstream product

• 288-32-4 1H-imidazole 
• 823-78-9 meta-bromobenzyl bromide 
• 591-17-3 meta-bromotoluene 

Downstream Products

• 1426937-33-8 C₁₇H₁₆N₄O₂ 
• 1426937-34-9 C₁₇H₁₇N₃O 
• 1426937-35-0 C₁₈H₁₇ClN₂O 
• 1426937-36-1 C₂₂H₁₈N₂O 
• 1426937-37-2 C₁₈H₁₈N₂O 
• 1426937-38-3 C₁₇H₁₆N₂O 
• 1426937-39-4 C₁₆H₁₃ClN₂O 
• 1426937-40-7 C₁₇H₁₆N₂O 
• 111371-15-4 C₁₆H₁₄N₂O 
• 912962-74-4 3-(3-((1H-imidazol-1-yl)methyl)phenyl)-N-(tert-butyl)-5-isobutylthiophene-2-sulfonamide 

Relevant articles and documents

A convenient transesterification method for synthesis of AT2 receptor ligands with improved stability in human liver microsomes

A series of AT2R ligands have been synthesized applying a quick, simple, and safe transesterification-type reaction whereby the sulfonyl carbamate alkyl tail of the selective AT2R antagonist C38 was varied. Furthermore, a limited number of compounds where acyl sulfonamides and sulfonyl ureas served as carboxylic acid bioisosteres were synthesized and evaluated. By reducing the size of the alkyl chain of the sulfonyl carbamates, ligands 7a and 7b were identified with significantly improved in vitro metabolic stability in both human and mouse liver microsomes as compared to C38 while retaining the AT2R binding affinity and AT2R/AT1R selectivity. Eight of the compounds synthesized exhibit an improved stability in human microsomes as compared to C38.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS

Cycloalkylnitrile pyrazole carboxamides as JAK inhibitors useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer are provided.