724788-66-3

Basic information

• Product Name: 4-broMo-6-Methoxy-1,5-naphthyridin-3-aMine
• Synonyms: 4-broMo-6-Methoxy-1,5-naphthyridin-3-aMine;(4-BroMo-6-Methoxy-[1,5]naphthyridin-3-yl)aMine
• CAS NO: 724788-66-3
• Molecular Formula: C9H8BrN3O
• Molecular Weight: 254.08332
• Mol File: 724788-66-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 374.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.666±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.92±0.30(Predicted)
• CAS DataBase Reference: 4-broMo-6-Methoxy-1,5-naphthyridin-3-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-6-Methoxy-1,5-naphthyridin-3-aMine(724788-66-3)
• EPA Substance Registry System: 4-broMo-6-Methoxy-1,5-naphthyridin-3-aMine(724788-66-3)

Safety Data

• Hazardous Substances Data: 724788-66-3(Hazardous Substances Data)

Upstream product

• 724788-65-2 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 1417551-48-4 t-butyl 4-bromo-6-methoxy-1,5-naphthyridine-3-yl-carbamate 
• 724788-67-4 (4-bromo-6-methoxy-[1,5]naphthyridin-3-ylamino)carbamic acid tert-butyl ester 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 
• 724788-64-1 ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate 
• 724788-63-0 ethyl 6-methoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate 
• 53241-90-0 diethyl {[(6-methoxypyridin-3-yl)amino]methylidene}propanedioate 
• 53241-92-2 4-Hydroxy-6-methoxy-[1,5]naphthyridine-3-carboxylic Acid Ethyl Ester 

Downstream Products

• 724788-70-9 8-bromo-7-fluoro-2-methoxy-1,5-naphthyridine 
• 1415415-01-8 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine 
• 1616409-89-2 t-butyl 1-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl)-2-oxabicyclo[2.2.2]octan-4-ylcarbamate 
• 1616409-88-1 t-butyl 1-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl)-2-oxabicyclo[2.2.2]octan-4-ylcarbamate 

Relevant articles and documents

Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents

Bacterial resistance is eroding the clinical utility of existing antibiotics necessitating the discovery of new agents. Bacterial type II topoisomerase is a clinically validated, highly effective, and proven drug target. This target is amenable to inhibit

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.

ANTIBACTERIAL AGENTS

Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.