7250-45-5

Basic information

• Product Name: N,N-bis(2-chloroethyl)phosphoric triamide
• Synonyms: N,N-Bis(2-chloroethyl)phosphoric triamide; phosphoric triamide, N,N-bis(2-chloroethyl)-
• CAS NO: 7250-45-5
• Molecular Formula: C₄H₁₂Cl₂N₃OP
• Molecular Weight: 220.0373
• Mol File: 7250-45-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 350.5°C at 760 mmHg
• Flash Point: 165.8°C
• Density: 1.409g/cm³
• Vapor Pressure: 4.38E-05mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: N,N-bis(2-chloroethyl)phosphoric triamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-chloroethyl)phosphoric triamide(7250-45-5)
• EPA Substance Registry System: N,N-bis(2-chloroethyl)phosphoric triamide(7250-45-5)

Safety Data

• Hazardous Substances Data: 7250-45-5(Hazardous Substances Data)

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 

Relevant articles and documents

Design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors

The design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors to reduce the loss of ammonia has been carried out. Forty phosphorus derivatives were synthesized and their inhibitory activities evaluated against that of jack bean urease. In addition, in vivo assays have been carried out. All of the compounds were characterized by IR, 1H NMR, MS, and elemental microanalysis. In some cases, detailed molecular modeling studies were carried out, and these highlighted the interaction between the enzyme active center and the compounds and also the characteristics related to their activity as urease inhibitors. According to the IC50 values for in vitro inhibitory activity, 12 compounds showed values below 1 μM and 8 of them represent improvements of activity in comparison to the commercial urease inhibitor N-n-butylthiophosphorictriamide (NBPT) (100 nM) (AGROTAIN). On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined.