72534-45-3

Basic information

• Product Name: 3-AMINO-2-HYDROXYBENZOTRIFLUORIDE
• Synonyms: 3-AMINO-2-HYDROXYBENZOTRIFLUORIDE;2-Hydroxy-3-(trifluoromethyl)aniline;2-Hydroxy-3-(trifluoromethyl)aniline, 2-Amino-6-(trifluoromethyl)phenol;2-aMino-6-(trifluoroMethyl)phenol
• CAS NO: 72534-45-3
• Molecular Formula: C₇H₆F₃NO
• Molecular Weight: 177.1238496
• Mol File: 72534-45-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 209.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.432±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.77±0.35(Predicted)
• CAS DataBase Reference: 3-AMINO-2-HYDROXYBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-HYDROXYBENZOTRIFLUORIDE(72534-45-3)
• EPA Substance Registry System: 3-AMINO-2-HYDROXYBENZOTRIFLUORIDE(72534-45-3)

Safety Data

• Hazardous Substances Data: 72534-45-3(Hazardous Substances Data)

Usage

General Description

3-AMINO-2-HYDROXYBENZOTRIFLUORIDE is a chemical compound with the molecular formula C7H6F3NO. It is a white to off-white solid commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. 3-AMINO-2-HYDROXYBENZOTRIFLUORIDE is a derivative of benzoic acid and contains a trifluoromethyl group, an amino group, and a hydroxy group. 3-AMINO-2-HYDROXYBENZOTRIFLUORIDE is used in various applications, including in the production of agrochemicals, dyes, and pigments. It is important to handle this substance with caution, as it may be harmful if swallowed, inhaled, or brought into contact with skin.

Upstream product

• 1548-62-5 2-Nitro-6-(trifluoromethyl)phenol 
• 7772-99-8 stannous chloride 
• 444-30-4 2-(trifluoromethyl)phenol 

Downstream Products

• 182498-97-1 N-[2-hydroxy-3-trifluoromethylphenyl]-N'-[2-bromophenyl] urea 
• 939759-08-7 8-(trifluoromethyl)-3,4-dihydro-2H-benzo[b][1,4]oxaazine 

Relevant articles and documents

Spiro derivative, preparation method thereof and application of spiro derivative in medicine

The invention relates to a spiro derivative, a preparation method thereof and application of the spiro derivative in medicine. Specifically, the invention relates to the spiro derivative shown in a general formula (I), the preparation method thereof, a pharmaceutical composition containing the spiro derivative and application of the spiro derivative as a therapeutic agent, especially application of the spiro derivative as an RAF inhibitor and application of the spiro derivative in preparation of drugs for treating or preventing various diseases (including cancers) related to over-expression RAF activity.

INHIBITORS OF HIF PROLYL HYDROXYLASE

The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

IL-8 RECEPTOR ANTAGONISTS

Novel IL-8 receptor antagonists and methods of using them are provided.