72590-77-3 Usage
Description
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate, also known as Hydrocortisone butyrate propionate, is a potent, synthetic adrenocorticosteroid with minimal systemic side effects. It is characterized by its anti-inflammatory and anti-pruritic properties, making it suitable for the treatment of various dermatologic disorders.
Uses
Used in Dermatology:
11beta,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate is used as a topical agent for the treatment of dermatologic disorders such as atopic dermatitis and psoriasis. It is effective in managing acute and chronic contact, eczematous, and atopic dermatoses, as well as psoriasis, due to its potent anti-inflammatory and anti-pruritic properties.
Originator
Taiaho (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 72590-77-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,5,9 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72590-77:
(7*7)+(6*2)+(5*5)+(4*9)+(3*0)+(2*7)+(1*7)=143
143 % 10 = 3
So 72590-77-3 is a valid CAS Registry Number.
InChI:InChI=1/C28H40O7/c1-5-7-24(33)35-28(22(31)16-34-23(32)6-2)13-11-20-19-9-8-17-14-18(29)10-12-26(17,3)25(19)21(30)15-27(20,28)4/h14,19-21,25,30H,5-13,15-16H2,1-4H3/t19-,20-,21-,25+,26-,27-,28-/m0/s1
72590-77-3Relevant articles and documents
Novel hydrocortisone derivative
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, (2008/06/13)
17α-butyryloxy-11β-hydroxy-21-propionyloxy-4-pregnen-3,20-dione, i.e., hydrocortisone 17-butyrate 21-propionate of the present invention is prepared by acylating hydrocortisone 17-butyrate with propionic acid anhydride or halide. The compound of the present invention has excellent anti-inflammatory effect, percutaneous absorption and less side effect.